Current management strategies for ovarian cancer

Giovanni D. Aletti, Mary M. Gallenberg, William Arthur Cliby, Aminah Jatoi, Lynn C. Hartmann

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

Epithelial ovarian cancer originates in the layer of cells that covers the surface of the ovaries. The disease spreads readily throughout the peritoneal cavity and to the lymphatics, often before causing symptoms. Of the cancers unique to women, diagnosed as having advanced stage disease, and efforts to develop new screening approaches for ovarian cancer are a high priority. Optimal treatment of ovarian cancer begins with optimal cytoreductive surgery followed by combination chemotherapy. Ovarian cancer, even in advanced stages, is sensitive to a variety of chemotherapeutics. Although improved chemotherapy has increased 5-year survival rates, overall survival gains have been limited because of our inability to eradicate all disease. Technologic advances that allow us to examine the molecular machinery that drives ovarian cancer cells have helped to identify numerous therapeutic targets within these cells. In this review, we provide an overview of ovarian cancer with perticular emphasis on recent advances in operative management and systemic therapies.

Original languageEnglish (US)
Pages (from-to)751-770
Number of pages20
JournalMayo Clinic Proceedings
Volume82
Issue number6
DOIs
StatePublished - 2007

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Ovarian Neoplasms
Peritoneal Cavity
Combination Drug Therapy
Ovary
Therapeutics
Survival Rate
Drug Therapy
Survival
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Current management strategies for ovarian cancer. / Aletti, Giovanni D.; Gallenberg, Mary M.; Cliby, William Arthur; Jatoi, Aminah; Hartmann, Lynn C.

In: Mayo Clinic Proceedings, Vol. 82, No. 6, 2007, p. 751-770.

Research output: Contribution to journalArticle

Aletti, GD, Gallenberg, MM, Cliby, WA, Jatoi, A & Hartmann, LC 2007, 'Current management strategies for ovarian cancer', Mayo Clinic Proceedings, vol. 82, no. 6, pp. 751-770. https://doi.org/10.4065/82.6.751
Aletti, Giovanni D. ; Gallenberg, Mary M. ; Cliby, William Arthur ; Jatoi, Aminah ; Hartmann, Lynn C. / Current management strategies for ovarian cancer. In: Mayo Clinic Proceedings. 2007 ; Vol. 82, No. 6. pp. 751-770.
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