Current imaging follow-up of non-Hodgkin lymphoma exposes patients to significant radiation but does not detect asymptomatic relapses

Eloisa Riva, Carolina Oliver, Maria Del Carmen Pérez, Osmar Telis, Lilian Díaz, Joseph R. Mikhael

Research output: Contribution to journalArticle

1 Scopus citations


The standard approach to the follow-up of lymphoma includes computed tomography (CT) every 6-12 months for the first 2 years and, then, as clinically indicated. Recent evidence suggests that most relapses are detected clinically, outside scheduled CT which, on the other hand, increases risk of second malignancies and cost. In early-stage lymphomas, involved site CT instead of full body CT may be a reasonable alternative to reduce radiation dose. We analyzed whether regular CT surveillance detects asymptomatic relapses in a single-center Uruguayan early stage non-Hodgkin lymphoma (NHL) population. We evaluated utility of full body CT halfway and at the end-of-treatment evaluation and calculated the radiation exposure. In our study, CT surveillance added nothing to clinical follow-up. Moreover, 44% of our patients received a cumulative effective dose that doubles the risk of malignancies. Involved-site CT scan would be enough to monitor response during treatment in early stage NHL.

Original languageEnglish (US)
Pages (from-to)1363-1366
Number of pages4
JournalLeukemia and Lymphoma
Issue number6
StatePublished - Jun 2 2016



  • Lymphoma and Hodgkin disease
  • prognostication
  • radiation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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