Current evidence and therapeutic strategies for multiple sclerosis

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

In the previous two decades several immunomodulatory and immunosuppressive therapies have been shown to favorably impact the inflammatory activity and course of multiple sclerosis. There are now six approved therapies for the disease. Clinical decision-making has become more complex because of the increasing number of available drugs, the lack of head-to-head comparisons that allow direct comparisons of efficacy, and special factors that may influence efficacy such as neutralizing antibodies against β-interferon preparations. Furthermore, all current therapies are partially effective; therefore, most patients experience breakthrough disease activity while using them, and there are no validated treatment failure definitions or management algorithms. This review outlines current evidence supporting efficacy of available drugs and scenarios for which more studies are required, and highlights the need for emerging therapies and strategies for multiple sclerosis management, including investigative oral and parenteral agents and combination therapy approaches.

Original languageEnglish (US)
Pages (from-to)56-68
Number of pages13
JournalSeminars in Neurology
Volume28
Issue number1
DOIs
StatePublished - Feb 1 2008

Keywords

  • Drug therapy
  • Glatiramer acetate
  • Immunosuppression
  • Mitoxantrone
  • Multiple sclerosis
  • Natalizumab
  • β-interferon

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Current evidence and therapeutic strategies for multiple sclerosis'. Together they form a unique fingerprint.

  • Cite this