TY - JOUR
T1 - Current epidemiology of mild cognitive impairment and other predementia syndromes
AU - Panza, Francesco
AU - D'Introno, Alessia
AU - Colacicco, Anna Maria
AU - Capurso, Cristiano
AU - Del Parigi, Angela
AU - Caselli, Richard J.
AU - Pilotto, Alberto
AU - Argentieri, Giovanni
AU - Scapicchio, Pier Luigi
AU - Scafato, Emanuele
AU - Capurso, Antonio
AU - Solfrizzi, Vincenzo
N1 - Funding Information:
This group is supported by the Italian Longitudinal Study on Aging (ILSA; Italian National Research Council, CNR-Targeted Project on Aging; grants 9400419PF40 and 95973PF40 ) and by AFORIGE (“Associazione per la Formazione e la Ricerca in Geriatria”).
PY - 2005/8
Y1 - 2005/8
N2 - A variety of clinically-defined predementia syndromes, with differing diagnostic criteria and nomenclature, have been proposed to describe nondisabling symptomatic cognitive deficits arising in elderly persons. Incidence and prevalence of different predementia syndromes vary as a result of different diagnostic criteria, sampling, and assessment procedures. The incidence rates of all predementia syndromes increase with age and are higher in subjects with less education; but age, educational background, and gender are not consistently related to prevalence rates. There is particular interest in "Mild Cognitive Impairment (MCI)" because this predementia syndrome is thought to be a prodromal phase of Alzheimer disease (AD). Several studies have suggested that most patients who meet MCI criteria will progress to AD, but rates of conversion to AD and dementia vary widely among studies. Furthermore, MCI definition is less consistent in population-based studies than clinical studies, in which progression to AD is also more consistent. To clarify the sources of discrepant findings in the literature, this review summarizes existing epidemiological studies of the defined clinical predementia syndromes and their progression to dementia.
AB - A variety of clinically-defined predementia syndromes, with differing diagnostic criteria and nomenclature, have been proposed to describe nondisabling symptomatic cognitive deficits arising in elderly persons. Incidence and prevalence of different predementia syndromes vary as a result of different diagnostic criteria, sampling, and assessment procedures. The incidence rates of all predementia syndromes increase with age and are higher in subjects with less education; but age, educational background, and gender are not consistently related to prevalence rates. There is particular interest in "Mild Cognitive Impairment (MCI)" because this predementia syndrome is thought to be a prodromal phase of Alzheimer disease (AD). Several studies have suggested that most patients who meet MCI criteria will progress to AD, but rates of conversion to AD and dementia vary widely among studies. Furthermore, MCI definition is less consistent in population-based studies than clinical studies, in which progression to AD is also more consistent. To clarify the sources of discrepant findings in the literature, this review summarizes existing epidemiological studies of the defined clinical predementia syndromes and their progression to dementia.
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U2 - 10.1097/00019442-200508000-00002
DO - 10.1097/00019442-200508000-00002
M3 - Article
C2 - 16085779
AN - SCOPUS:23944439861
SN - 1064-7481
VL - 13
SP - 633
EP - 644
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 8
ER -