Current concepts in penile cancer

Philippe E. Spiess, Simon Horenblas, Lance C. Pagliaro, Matthew C. Biagioli, Juanita Crook, Peter E. Clark, Richard E. Greenberg, Cesar E. Ercole

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

This review highlights the significant advances made in the diagnosis and management of penile cancer. This often-aggressive tumor phenotype has been characterized by its poor prognosis, mostly attributable to its late presentation and heterogeneity of surgical care because of the paucity of cases treated at most centers. Recent advances in understanding of the risk factors predisposing to penile cancer, including its association with the human papilloma virus (HPV), have brought forth the socioepidemiologic concept of HPV vaccination in certain high-risk populations and countries, which remains highly debated. The management of penile cancer has evolved in recent years with the adoption of penile-sparing and minimally invasive surgical approaches to the inguinal lymph nodes, which are a frequent site of regional spread for this malignancy. Lastly, this review highlights the importance of adopting a multimodal approach consisting of neoadjuvant systemic chemotherapy followed by consolidative surgical resection in patients presenting with bulky/locally advanced nodal metastases from penile cancer.

Original languageEnglish (US)
Pages (from-to)617-624
Number of pages8
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume11
Issue number5
StatePublished - 2013
Externally publishedYes

Fingerprint

Penile Neoplasms
Papillomaviridae
Groin
Neoplasms
Vaccination
Lymph Nodes
Neoplasm Metastasis
Phenotype
Drug Therapy
Population

ASJC Scopus subject areas

  • Oncology

Cite this

Spiess, P. E., Horenblas, S., Pagliaro, L. C., Biagioli, M. C., Crook, J., Clark, P. E., ... Ercole, C. E. (2013). Current concepts in penile cancer. JNCCN Journal of the National Comprehensive Cancer Network, 11(5), 617-624.

Current concepts in penile cancer. / Spiess, Philippe E.; Horenblas, Simon; Pagliaro, Lance C.; Biagioli, Matthew C.; Crook, Juanita; Clark, Peter E.; Greenberg, Richard E.; Ercole, Cesar E.

In: JNCCN Journal of the National Comprehensive Cancer Network, Vol. 11, No. 5, 2013, p. 617-624.

Research output: Contribution to journalReview article

Spiess, PE, Horenblas, S, Pagliaro, LC, Biagioli, MC, Crook, J, Clark, PE, Greenberg, RE & Ercole, CE 2013, 'Current concepts in penile cancer', JNCCN Journal of the National Comprehensive Cancer Network, vol. 11, no. 5, pp. 617-624.
Spiess PE, Horenblas S, Pagliaro LC, Biagioli MC, Crook J, Clark PE et al. Current concepts in penile cancer. JNCCN Journal of the National Comprehensive Cancer Network. 2013;11(5):617-624.
Spiess, Philippe E. ; Horenblas, Simon ; Pagliaro, Lance C. ; Biagioli, Matthew C. ; Crook, Juanita ; Clark, Peter E. ; Greenberg, Richard E. ; Ercole, Cesar E. / Current concepts in penile cancer. In: JNCCN Journal of the National Comprehensive Cancer Network. 2013 ; Vol. 11, No. 5. pp. 617-624.
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