Current and potential future trends in the management of the brain-dead organ donor

Octavio E. Pajaro, James K. Kirklin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Despite advances in the prevention and treatment of end-stage organ-failure, solid-organ transplantation remains for many the best option for improving the quality of life and the likelihood of survival. Procurement of organs from brain-dead donors is the only option for the majority of patients with end-stage heart and lung failure needing and qualifying for transplantation. It has been known for quite some time, however, that the brain death process can lead to a pathophysiologic cascade that potentially produces significant donor organ dysfunction. As a result, a significant effort has been made to explore approaches to improve donor organ function by removing the organ from the brain death milieu and by protecting the organs in vivo and ex vivo from the cascade of events that is initiated during the brain death process and the inevitable and obligatory ischemia-reperfusion event. This chapter summarizes some of the exciting approaches ranging from attempts at improving the logistics of donor procurement to controlling the molecular events that lead to organ dysfunction. Thankfully, the altruism of truly generous families and donors offers hope to many.

Original languageEnglish (US)
Title of host publicationThe Brain-Dead Organ Donor: Pathophysiology and Management
PublisherSpringer New York
Pages333-341
Number of pages9
Volume9781461443049
ISBN (Print)9781461443049, 1461443032, 9781461443032
DOIs
StatePublished - Mar 1 2013

Fingerprint

Brain Death
Tissue Donors
Hope
Altruism
Tissue and Organ Procurement
Organ Transplantation
Reperfusion
Ischemia
Heart Failure
Transplantation
Quality of Life
Lung
Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pajaro, O. E., & Kirklin, J. K. (2013). Current and potential future trends in the management of the brain-dead organ donor. In The Brain-Dead Organ Donor: Pathophysiology and Management (Vol. 9781461443049, pp. 333-341). Springer New York. https://doi.org/10.1007/978-1-4614-4304-9_27

Current and potential future trends in the management of the brain-dead organ donor. / Pajaro, Octavio E.; Kirklin, James K.

The Brain-Dead Organ Donor: Pathophysiology and Management. Vol. 9781461443049 Springer New York, 2013. p. 333-341.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pajaro, OE & Kirklin, JK 2013, Current and potential future trends in the management of the brain-dead organ donor. in The Brain-Dead Organ Donor: Pathophysiology and Management. vol. 9781461443049, Springer New York, pp. 333-341. https://doi.org/10.1007/978-1-4614-4304-9_27
Pajaro OE, Kirklin JK. Current and potential future trends in the management of the brain-dead organ donor. In The Brain-Dead Organ Donor: Pathophysiology and Management. Vol. 9781461443049. Springer New York. 2013. p. 333-341 https://doi.org/10.1007/978-1-4614-4304-9_27
Pajaro, Octavio E. ; Kirklin, James K. / Current and potential future trends in the management of the brain-dead organ donor. The Brain-Dead Organ Donor: Pathophysiology and Management. Vol. 9781461443049 Springer New York, 2013. pp. 333-341
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