Curcumin and osteosarcoma: Can invertible polymeric micelles help?

Avudaiappan Maran, Michael J. Yaszemski, Ananiy Kohut, Andriy Voronov

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Systematic review of experimental and clinical data on the use of curcumin in the treatment of osteosarcoma is presented. The current status of curcumin's therapeutic potential against bone cancer is analyzed in regard to using polymeric micelles (including recently developed invertible, responsive, micelles) as a platform for curcumin delivery to treat osteosarcoma. The potential of micellar assemblies from responsive macromolecules in a controlled delivery of curcumin to osteosarcoma cells, and the release using a new inversion mechanism is revealed.

Original languageEnglish (US)
Article number520
JournalMaterials
Volume9
Issue number7
DOIs
StatePublished - Jul 2016

Keywords

  • Bone tumor treatment
  • Curcumin delivery
  • Invertible polymer micelles
  • Micellar nanoassemblies

ASJC Scopus subject areas

  • Materials Science(all)

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