TY - JOUR
T1 - Curcumin and osteosarcoma
T2 - Can invertible polymeric micelles help?
AU - Maran, Avudaiappan
AU - Yaszemski, Michael J.
AU - Kohut, Ananiy
AU - Voronov, Andriy
N1 - Publisher Copyright:
© 2016 by the authors.
PY - 2016/7
Y1 - 2016/7
N2 - Systematic review of experimental and clinical data on the use of curcumin in the treatment of osteosarcoma is presented. The current status of curcumin's therapeutic potential against bone cancer is analyzed in regard to using polymeric micelles (including recently developed invertible, responsive, micelles) as a platform for curcumin delivery to treat osteosarcoma. The potential of micellar assemblies from responsive macromolecules in a controlled delivery of curcumin to osteosarcoma cells, and the release using a new inversion mechanism is revealed.
AB - Systematic review of experimental and clinical data on the use of curcumin in the treatment of osteosarcoma is presented. The current status of curcumin's therapeutic potential against bone cancer is analyzed in regard to using polymeric micelles (including recently developed invertible, responsive, micelles) as a platform for curcumin delivery to treat osteosarcoma. The potential of micellar assemblies from responsive macromolecules in a controlled delivery of curcumin to osteosarcoma cells, and the release using a new inversion mechanism is revealed.
KW - Bone tumor treatment
KW - Curcumin delivery
KW - Invertible polymer micelles
KW - Micellar nanoassemblies
UR - http://www.scopus.com/inward/record.url?scp=84977606206&partnerID=8YFLogxK
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U2 - 10.3390/ma9070520
DO - 10.3390/ma9070520
M3 - Article
AN - SCOPUS:84977606206
SN - 1996-1944
VL - 9
JO - Materials
JF - Materials
IS - 7
M1 - 520
ER -