Curative external beam radiotherapy in patients over 80 years of age with localized prostate cancer: A retrospective rare cancer network study

Tan Dat Nguyen, David Azria, Daniele Brochon, Philip Poortmans, Robert C. Miller, Luciano Scandolaro, Wojciech Majewski, Marco Krengli, Ufuk Abacioglu, Luigi Moretti, Salvador Villa, Fadil Akyol, Nicolas Jovenin

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Purpose: To analyse tolerance and outcome of patients over 80 years of age who choose external beam radiation therapy to the prostate as a curative treatment. Methods and material: We evaluated acute and late side effects, biological DFS (bDFS) and actuarial survival as well as causes of death in relation to the clinical status including co-morbidity, PSA value, Gleason score and modalities of external radiotherapy in patients with localised prostate cancer >80 years of age. Results: From January 1990 to December 2000, 65 eligible cases (median age: 81) were treated by 12 different participating institutions in the Rare Cancer Network. Tumour stage was T1N0M0, T2N0M0 and T3N0M0 for 10, 40, and 15 patients, respectively. Median follow-up was 65 months (range 22-177). Five-year overall survival rate was 77% with a 5-year bDFS rate of 73%. The incidence of grade 3 early toxicity was 12% and 9% for urinary and digestive tract, respectively. Conclusions: Radiation therapy given with curative intent is well tolerated in this selected group of patients aged over 80 years with localised prostate cancer. Results in terms of survival do not suggest a deleterious impact of this treatment. Therefore the authors recommend that radiation therapy with curative intent should not be withheld in selected elderly patients with localised prostate cancer.

Original languageEnglish (US)
Pages (from-to)66-71
Number of pages6
JournalCritical Reviews in Oncology/Hematology
Volume74
Issue number1
DOIs
StatePublished - Apr 1 2010

Keywords

  • Curative treatment
  • Elderly
  • Prostate cancer
  • Radiotherapy
  • Side effects

ASJC Scopus subject areas

  • Hematology
  • Oncology

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    Nguyen, T. D., Azria, D., Brochon, D., Poortmans, P., Miller, R. C., Scandolaro, L., Majewski, W., Krengli, M., Abacioglu, U., Moretti, L., Villa, S., Akyol, F., & Jovenin, N. (2010). Curative external beam radiotherapy in patients over 80 years of age with localized prostate cancer: A retrospective rare cancer network study. Critical Reviews in Oncology/Hematology, 74(1), 66-71. https://doi.org/10.1016/j.critrevonc.2009.04.004