CUBN is a gene locus for albuminuria

Carsten A. Böger, Ming Huei Chen, Adrienne Tin, Matthias Olden, Anna Köttgen, Ian H. de Boer, Christian Fuchsberger, Conall M. O'Seaghdha, Cristian Pattaro, Alexander Teumer, Ching Ti Liu, Nicole L. Glazer, Man Li, Jeffrey R. O'Connell, Toshiko Tanaka, Carmen A. Peralta, Zoltán Kutalik, Jian'an Luan, Jing Hua Zhao, Shih Jen HwangErmeg Akylbekova, Holly Kramer, Pim van der Harst, Albert V. Smith, Kurt Lohman, Mariza De Andrade, Caroline Hayward, Barbara Kollerits, Anke Tönjes, Thor Aspelund, Erik Ingelsson, Gudny Eiriksdottir, Lenore J. Launer, Tamara B. Harris, Alan R. Shuldiner, Braxton D. Mitchell, Dan E. Arking, Nora Franceschini, Eric Boerwinkle, Josephine Egan, Dena Hernandez, Muredach Reilly, Raymond R. Townsend, Thomas Lumley, David S. Siscovick, Bruce M. Psaty, Bryan Kestenbaum, Talin Haritunians, Sven Bergmann, Peter Vollenweider, Gerard Waeber, Vincent Mooser, Dawn Waterworth, Andrew D. Johnson, Jose C. Florez, James B. Meigs, Xiaoning Lu, Stephen T Turner, Elizabeth J. Atkinson, Tennille S. Leak, Knut Aasarød, Frank Skorpen, Ann Christine Syvänen, Thomas Illig, Jens Baumert, Wolfgang Koenig, Bernhard K. Krämer, Olivier Devuyst, Josyf C. Mychaleckyj, Cosetta Minelli, Stephan J L Bakker, Lyudmyla Kedenko, Bernhard Paulweber, Stefan Coassin, Karlhans Endlich, Heyo K. Kroemer, Reiner Biffar, Sylvia Stracke, Henry Völzke, Michael Stumvoll, Reedik Mägi, Harry Campbell, Veronique Vitart, Nicholas D. Hastie, Vilmundur Gudnason, Sharon L R Kardia, Yongmei Liu, Ozren Polasek, Gary Curhan, Florian Kronenberg, Inga Prokopenko, Igor Rudan, Johan Ärnlöv, Stein Hallan, Gerjan Navis, Afshin Parsa, Luigi Ferrucci, Josef Coresh, Michael G. Shlipak, Shelley B. Bull, Andrew D. Paterson, H. Erich Wichmann, Nicholas J. Wareham, Ruth J F Loos, Jerome I. Rotter, Peter P. Pramstaller, L. A. Adrienne Cupples, Jacques S. Beckmann, Qiong Yang, Iris M. Heid, Rainer Rettig, Albert W. Dreisbach, Murielle Bochud, Caroline S. Fox, W. H. Linda Kao

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general and diabetic populations. We performed a meta-analysis of data from 63,153 individuals of European ancestry with genotype information from genome-wide association studies (CKDGen Consortium) and from a large candidate gene study (CARe Consortium) to identify susceptibility loci for the quantitative trait urinary albumin-to-creatinine ratio (UACR) and the clinical diagnosis microalbuminuria. We identified an association between a missense variant (I2984V) in the CUBN gene, which encodes cubilin, and both UACR (P = 1.1 × 10-11) and microalbuminuria (P = 0.001). We observed similar associations among 6981 African Americans in the CARe Consortium. The associations between this variant and both UACR and microalbuminuria were significant in individuals of European ancestry regardless of diabetes status. Finally, this variant associated with a 41% increased risk for the development of persistent microalbuminuria during 20 years of follow-up among 1304 participants with type 1 diabetes in the prospective DCCT/EDIC Study. In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes.

Original languageEnglish (US)
Pages (from-to)555-570
Number of pages16
JournalJournal of the American Society of Nephrology
Volume22
Issue number3
DOIs
StatePublished - Mar 2011

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Albuminuria
Albumins
Creatinine
Genes
Quantitative Trait Loci
Genome-Wide Association Study
Type 1 Diabetes Mellitus
African Americans
Population
Meta-Analysis
Genotype

ASJC Scopus subject areas

  • Nephrology

Cite this

Böger, C. A., Chen, M. H., Tin, A., Olden, M., Köttgen, A., de Boer, I. H., ... Linda Kao, W. H. (2011). CUBN is a gene locus for albuminuria. Journal of the American Society of Nephrology, 22(3), 555-570. https://doi.org/10.1681/ASN.2010060598

CUBN is a gene locus for albuminuria. / Böger, Carsten A.; Chen, Ming Huei; Tin, Adrienne; Olden, Matthias; Köttgen, Anna; de Boer, Ian H.; Fuchsberger, Christian; O'Seaghdha, Conall M.; Pattaro, Cristian; Teumer, Alexander; Liu, Ching Ti; Glazer, Nicole L.; Li, Man; O'Connell, Jeffrey R.; Tanaka, Toshiko; Peralta, Carmen A.; Kutalik, Zoltán; Luan, Jian'an; Zhao, Jing Hua; Hwang, Shih Jen; Akylbekova, Ermeg; Kramer, Holly; van der Harst, Pim; Smith, Albert V.; Lohman, Kurt; De Andrade, Mariza; Hayward, Caroline; Kollerits, Barbara; Tönjes, Anke; Aspelund, Thor; Ingelsson, Erik; Eiriksdottir, Gudny; Launer, Lenore J.; Harris, Tamara B.; Shuldiner, Alan R.; Mitchell, Braxton D.; Arking, Dan E.; Franceschini, Nora; Boerwinkle, Eric; Egan, Josephine; Hernandez, Dena; Reilly, Muredach; Townsend, Raymond R.; Lumley, Thomas; Siscovick, David S.; Psaty, Bruce M.; Kestenbaum, Bryan; Haritunians, Talin; Bergmann, Sven; Vollenweider, Peter; Waeber, Gerard; Mooser, Vincent; Waterworth, Dawn; Johnson, Andrew D.; Florez, Jose C.; Meigs, James B.; Lu, Xiaoning; Turner, Stephen T; Atkinson, Elizabeth J.; Leak, Tennille S.; Aasarød, Knut; Skorpen, Frank; Syvänen, Ann Christine; Illig, Thomas; Baumert, Jens; Koenig, Wolfgang; Krämer, Bernhard K.; Devuyst, Olivier; Mychaleckyj, Josyf C.; Minelli, Cosetta; Bakker, Stephan J L; Kedenko, Lyudmyla; Paulweber, Bernhard; Coassin, Stefan; Endlich, Karlhans; Kroemer, Heyo K.; Biffar, Reiner; Stracke, Sylvia; Völzke, Henry; Stumvoll, Michael; Mägi, Reedik; Campbell, Harry; Vitart, Veronique; Hastie, Nicholas D.; Gudnason, Vilmundur; Kardia, Sharon L R; Liu, Yongmei; Polasek, Ozren; Curhan, Gary; Kronenberg, Florian; Prokopenko, Inga; Rudan, Igor; Ärnlöv, Johan; Hallan, Stein; Navis, Gerjan; Parsa, Afshin; Ferrucci, Luigi; Coresh, Josef; Shlipak, Michael G.; Bull, Shelley B.; Paterson, Andrew D.; Wichmann, H. Erich; Wareham, Nicholas J.; Loos, Ruth J F; Rotter, Jerome I.; Pramstaller, Peter P.; Adrienne Cupples, L. A.; Beckmann, Jacques S.; Yang, Qiong; Heid, Iris M.; Rettig, Rainer; Dreisbach, Albert W.; Bochud, Murielle; Fox, Caroline S.; Linda Kao, W. H.

In: Journal of the American Society of Nephrology, Vol. 22, No. 3, 03.2011, p. 555-570.

Research output: Contribution to journalArticle

Böger, CA, Chen, MH, Tin, A, Olden, M, Köttgen, A, de Boer, IH, Fuchsberger, C, O'Seaghdha, CM, Pattaro, C, Teumer, A, Liu, CT, Glazer, NL, Li, M, O'Connell, JR, Tanaka, T, Peralta, CA, Kutalik, Z, Luan, J, Zhao, JH, Hwang, SJ, Akylbekova, E, Kramer, H, van der Harst, P, Smith, AV, Lohman, K, De Andrade, M, Hayward, C, Kollerits, B, Tönjes, A, Aspelund, T, Ingelsson, E, Eiriksdottir, G, Launer, LJ, Harris, TB, Shuldiner, AR, Mitchell, BD, Arking, DE, Franceschini, N, Boerwinkle, E, Egan, J, Hernandez, D, Reilly, M, Townsend, RR, Lumley, T, Siscovick, DS, Psaty, BM, Kestenbaum, B, Haritunians, T, Bergmann, S, Vollenweider, P, Waeber, G, Mooser, V, Waterworth, D, Johnson, AD, Florez, JC, Meigs, JB, Lu, X, Turner, ST, Atkinson, EJ, Leak, TS, Aasarød, K, Skorpen, F, Syvänen, AC, Illig, T, Baumert, J, Koenig, W, Krämer, BK, Devuyst, O, Mychaleckyj, JC, Minelli, C, Bakker, SJL, Kedenko, L, Paulweber, B, Coassin, S, Endlich, K, Kroemer, HK, Biffar, R, Stracke, S, Völzke, H, Stumvoll, M, Mägi, R, Campbell, H, Vitart, V, Hastie, ND, Gudnason, V, Kardia, SLR, Liu, Y, Polasek, O, Curhan, G, Kronenberg, F, Prokopenko, I, Rudan, I, Ärnlöv, J, Hallan, S, Navis, G, Parsa, A, Ferrucci, L, Coresh, J, Shlipak, MG, Bull, SB, Paterson, AD, Wichmann, HE, Wareham, NJ, Loos, RJF, Rotter, JI, Pramstaller, PP, Adrienne Cupples, LA, Beckmann, JS, Yang, Q, Heid, IM, Rettig, R, Dreisbach, AW, Bochud, M, Fox, CS & Linda Kao, WH 2011, 'CUBN is a gene locus for albuminuria', Journal of the American Society of Nephrology, vol. 22, no. 3, pp. 555-570. https://doi.org/10.1681/ASN.2010060598
Böger CA, Chen MH, Tin A, Olden M, Köttgen A, de Boer IH et al. CUBN is a gene locus for albuminuria. Journal of the American Society of Nephrology. 2011 Mar;22(3):555-570. https://doi.org/10.1681/ASN.2010060598
Böger, Carsten A. ; Chen, Ming Huei ; Tin, Adrienne ; Olden, Matthias ; Köttgen, Anna ; de Boer, Ian H. ; Fuchsberger, Christian ; O'Seaghdha, Conall M. ; Pattaro, Cristian ; Teumer, Alexander ; Liu, Ching Ti ; Glazer, Nicole L. ; Li, Man ; O'Connell, Jeffrey R. ; Tanaka, Toshiko ; Peralta, Carmen A. ; Kutalik, Zoltán ; Luan, Jian'an ; Zhao, Jing Hua ; Hwang, Shih Jen ; Akylbekova, Ermeg ; Kramer, Holly ; van der Harst, Pim ; Smith, Albert V. ; Lohman, Kurt ; De Andrade, Mariza ; Hayward, Caroline ; Kollerits, Barbara ; Tönjes, Anke ; Aspelund, Thor ; Ingelsson, Erik ; Eiriksdottir, Gudny ; Launer, Lenore J. ; Harris, Tamara B. ; Shuldiner, Alan R. ; Mitchell, Braxton D. ; Arking, Dan E. ; Franceschini, Nora ; Boerwinkle, Eric ; Egan, Josephine ; Hernandez, Dena ; Reilly, Muredach ; Townsend, Raymond R. ; Lumley, Thomas ; Siscovick, David S. ; Psaty, Bruce M. ; Kestenbaum, Bryan ; Haritunians, Talin ; Bergmann, Sven ; Vollenweider, Peter ; Waeber, Gerard ; Mooser, Vincent ; Waterworth, Dawn ; Johnson, Andrew D. ; Florez, Jose C. ; Meigs, James B. ; Lu, Xiaoning ; Turner, Stephen T ; Atkinson, Elizabeth J. ; Leak, Tennille S. ; Aasarød, Knut ; Skorpen, Frank ; Syvänen, Ann Christine ; Illig, Thomas ; Baumert, Jens ; Koenig, Wolfgang ; Krämer, Bernhard K. ; Devuyst, Olivier ; Mychaleckyj, Josyf C. ; Minelli, Cosetta ; Bakker, Stephan J L ; Kedenko, Lyudmyla ; Paulweber, Bernhard ; Coassin, Stefan ; Endlich, Karlhans ; Kroemer, Heyo K. ; Biffar, Reiner ; Stracke, Sylvia ; Völzke, Henry ; Stumvoll, Michael ; Mägi, Reedik ; Campbell, Harry ; Vitart, Veronique ; Hastie, Nicholas D. ; Gudnason, Vilmundur ; Kardia, Sharon L R ; Liu, Yongmei ; Polasek, Ozren ; Curhan, Gary ; Kronenberg, Florian ; Prokopenko, Inga ; Rudan, Igor ; Ärnlöv, Johan ; Hallan, Stein ; Navis, Gerjan ; Parsa, Afshin ; Ferrucci, Luigi ; Coresh, Josef ; Shlipak, Michael G. ; Bull, Shelley B. ; Paterson, Andrew D. ; Wichmann, H. Erich ; Wareham, Nicholas J. ; Loos, Ruth J F ; Rotter, Jerome I. ; Pramstaller, Peter P. ; Adrienne Cupples, L. A. ; Beckmann, Jacques S. ; Yang, Qiong ; Heid, Iris M. ; Rettig, Rainer ; Dreisbach, Albert W. ; Bochud, Murielle ; Fox, Caroline S. ; Linda Kao, W. H. / CUBN is a gene locus for albuminuria. In: Journal of the American Society of Nephrology. 2011 ; Vol. 22, No. 3. pp. 555-570.
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title = "CUBN is a gene locus for albuminuria",
abstract = "Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general and diabetic populations. We performed a meta-analysis of data from 63,153 individuals of European ancestry with genotype information from genome-wide association studies (CKDGen Consortium) and from a large candidate gene study (CARe Consortium) to identify susceptibility loci for the quantitative trait urinary albumin-to-creatinine ratio (UACR) and the clinical diagnosis microalbuminuria. We identified an association between a missense variant (I2984V) in the CUBN gene, which encodes cubilin, and both UACR (P = 1.1 × 10-11) and microalbuminuria (P = 0.001). We observed similar associations among 6981 African Americans in the CARe Consortium. The associations between this variant and both UACR and microalbuminuria were significant in individuals of European ancestry regardless of diabetes status. Finally, this variant associated with a 41{\%} increased risk for the development of persistent microalbuminuria during 20 years of follow-up among 1304 participants with type 1 diabetes in the prospective DCCT/EDIC Study. In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes.",
author = "B{\"o}ger, {Carsten A.} and Chen, {Ming Huei} and Adrienne Tin and Matthias Olden and Anna K{\"o}ttgen and {de Boer}, {Ian H.} and Christian Fuchsberger and O'Seaghdha, {Conall M.} and Cristian Pattaro and Alexander Teumer and Liu, {Ching Ti} and Glazer, {Nicole L.} and Man Li and O'Connell, {Jeffrey R.} and Toshiko Tanaka and Peralta, {Carmen A.} and Zolt{\'a}n Kutalik and Jian'an Luan and Zhao, {Jing Hua} and Hwang, {Shih Jen} and Ermeg Akylbekova and Holly Kramer and {van der Harst}, Pim and Smith, {Albert V.} and Kurt Lohman and {De Andrade}, Mariza and Caroline Hayward and Barbara Kollerits and Anke T{\"o}njes and Thor Aspelund and Erik Ingelsson and Gudny Eiriksdottir and Launer, {Lenore J.} and Harris, {Tamara B.} and Shuldiner, {Alan R.} and Mitchell, {Braxton D.} and Arking, {Dan E.} and Nora Franceschini and Eric Boerwinkle and Josephine Egan and Dena Hernandez and Muredach Reilly and Townsend, {Raymond R.} and Thomas Lumley and Siscovick, {David S.} and Psaty, {Bruce M.} and Bryan Kestenbaum and Talin Haritunians and Sven Bergmann and Peter Vollenweider and Gerard Waeber and Vincent Mooser and Dawn Waterworth and Johnson, {Andrew D.} and Florez, {Jose C.} and Meigs, {James B.} and Xiaoning Lu and Turner, {Stephen T} and Atkinson, {Elizabeth J.} and Leak, {Tennille S.} and Knut Aasar{\o}d and Frank Skorpen and Syv{\"a}nen, {Ann Christine} and Thomas Illig and Jens Baumert and Wolfgang Koenig and Kr{\"a}mer, {Bernhard K.} and Olivier Devuyst and Mychaleckyj, {Josyf C.} and Cosetta Minelli and Bakker, {Stephan J L} and Lyudmyla Kedenko and Bernhard Paulweber and Stefan Coassin and Karlhans Endlich and Kroemer, {Heyo K.} and Reiner Biffar and Sylvia Stracke and Henry V{\"o}lzke and Michael Stumvoll and Reedik M{\"a}gi and Harry Campbell and Veronique Vitart and Hastie, {Nicholas D.} and Vilmundur Gudnason and Kardia, {Sharon L R} and Yongmei Liu and Ozren Polasek and Gary Curhan and Florian Kronenberg and Inga Prokopenko and Igor Rudan and Johan {\"A}rnl{\"o}v and Stein Hallan and Gerjan Navis and Afshin Parsa and Luigi Ferrucci and Josef Coresh and Shlipak, {Michael G.} and Bull, {Shelley B.} and Paterson, {Andrew D.} and Wichmann, {H. Erich} and Wareham, {Nicholas J.} and Loos, {Ruth J F} and Rotter, {Jerome I.} and Pramstaller, {Peter P.} and {Adrienne Cupples}, {L. A.} and Beckmann, {Jacques S.} and Qiong Yang and Heid, {Iris M.} and Rainer Rettig and Dreisbach, {Albert W.} and Murielle Bochud and Fox, {Caroline S.} and {Linda Kao}, {W. H.}",
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TY - JOUR

T1 - CUBN is a gene locus for albuminuria

AU - Böger, Carsten A.

AU - Chen, Ming Huei

AU - Tin, Adrienne

AU - Olden, Matthias

AU - Köttgen, Anna

AU - de Boer, Ian H.

AU - Fuchsberger, Christian

AU - O'Seaghdha, Conall M.

AU - Pattaro, Cristian

AU - Teumer, Alexander

AU - Liu, Ching Ti

AU - Glazer, Nicole L.

AU - Li, Man

AU - O'Connell, Jeffrey R.

AU - Tanaka, Toshiko

AU - Peralta, Carmen A.

AU - Kutalik, Zoltán

AU - Luan, Jian'an

AU - Zhao, Jing Hua

AU - Hwang, Shih Jen

AU - Akylbekova, Ermeg

AU - Kramer, Holly

AU - van der Harst, Pim

AU - Smith, Albert V.

AU - Lohman, Kurt

AU - De Andrade, Mariza

AU - Hayward, Caroline

AU - Kollerits, Barbara

AU - Tönjes, Anke

AU - Aspelund, Thor

AU - Ingelsson, Erik

AU - Eiriksdottir, Gudny

AU - Launer, Lenore J.

AU - Harris, Tamara B.

AU - Shuldiner, Alan R.

AU - Mitchell, Braxton D.

AU - Arking, Dan E.

AU - Franceschini, Nora

AU - Boerwinkle, Eric

AU - Egan, Josephine

AU - Hernandez, Dena

AU - Reilly, Muredach

AU - Townsend, Raymond R.

AU - Lumley, Thomas

AU - Siscovick, David S.

AU - Psaty, Bruce M.

AU - Kestenbaum, Bryan

AU - Haritunians, Talin

AU - Bergmann, Sven

AU - Vollenweider, Peter

AU - Waeber, Gerard

AU - Mooser, Vincent

AU - Waterworth, Dawn

AU - Johnson, Andrew D.

AU - Florez, Jose C.

AU - Meigs, James B.

AU - Lu, Xiaoning

AU - Turner, Stephen T

AU - Atkinson, Elizabeth J.

AU - Leak, Tennille S.

AU - Aasarød, Knut

AU - Skorpen, Frank

AU - Syvänen, Ann Christine

AU - Illig, Thomas

AU - Baumert, Jens

AU - Koenig, Wolfgang

AU - Krämer, Bernhard K.

AU - Devuyst, Olivier

AU - Mychaleckyj, Josyf C.

AU - Minelli, Cosetta

AU - Bakker, Stephan J L

AU - Kedenko, Lyudmyla

AU - Paulweber, Bernhard

AU - Coassin, Stefan

AU - Endlich, Karlhans

AU - Kroemer, Heyo K.

AU - Biffar, Reiner

AU - Stracke, Sylvia

AU - Völzke, Henry

AU - Stumvoll, Michael

AU - Mägi, Reedik

AU - Campbell, Harry

AU - Vitart, Veronique

AU - Hastie, Nicholas D.

AU - Gudnason, Vilmundur

AU - Kardia, Sharon L R

AU - Liu, Yongmei

AU - Polasek, Ozren

AU - Curhan, Gary

AU - Kronenberg, Florian

AU - Prokopenko, Inga

AU - Rudan, Igor

AU - Ärnlöv, Johan

AU - Hallan, Stein

AU - Navis, Gerjan

AU - Parsa, Afshin

AU - Ferrucci, Luigi

AU - Coresh, Josef

AU - Shlipak, Michael G.

AU - Bull, Shelley B.

AU - Paterson, Andrew D.

AU - Wichmann, H. Erich

AU - Wareham, Nicholas J.

AU - Loos, Ruth J F

AU - Rotter, Jerome I.

AU - Pramstaller, Peter P.

AU - Adrienne Cupples, L. A.

AU - Beckmann, Jacques S.

AU - Yang, Qiong

AU - Heid, Iris M.

AU - Rettig, Rainer

AU - Dreisbach, Albert W.

AU - Bochud, Murielle

AU - Fox, Caroline S.

AU - Linda Kao, W. H.

PY - 2011/3

Y1 - 2011/3

N2 - Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general and diabetic populations. We performed a meta-analysis of data from 63,153 individuals of European ancestry with genotype information from genome-wide association studies (CKDGen Consortium) and from a large candidate gene study (CARe Consortium) to identify susceptibility loci for the quantitative trait urinary albumin-to-creatinine ratio (UACR) and the clinical diagnosis microalbuminuria. We identified an association between a missense variant (I2984V) in the CUBN gene, which encodes cubilin, and both UACR (P = 1.1 × 10-11) and microalbuminuria (P = 0.001). We observed similar associations among 6981 African Americans in the CARe Consortium. The associations between this variant and both UACR and microalbuminuria were significant in individuals of European ancestry regardless of diabetes status. Finally, this variant associated with a 41% increased risk for the development of persistent microalbuminuria during 20 years of follow-up among 1304 participants with type 1 diabetes in the prospective DCCT/EDIC Study. In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes.

AB - Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general and diabetic populations. We performed a meta-analysis of data from 63,153 individuals of European ancestry with genotype information from genome-wide association studies (CKDGen Consortium) and from a large candidate gene study (CARe Consortium) to identify susceptibility loci for the quantitative trait urinary albumin-to-creatinine ratio (UACR) and the clinical diagnosis microalbuminuria. We identified an association between a missense variant (I2984V) in the CUBN gene, which encodes cubilin, and both UACR (P = 1.1 × 10-11) and microalbuminuria (P = 0.001). We observed similar associations among 6981 African Americans in the CARe Consortium. The associations between this variant and both UACR and microalbuminuria were significant in individuals of European ancestry regardless of diabetes status. Finally, this variant associated with a 41% increased risk for the development of persistent microalbuminuria during 20 years of follow-up among 1304 participants with type 1 diabetes in the prospective DCCT/EDIC Study. In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes.

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