CT volumetry for gastric carcinoma: association with TNM stage

James T P D Hallinan, Sudhakar K Venkatesh, Luke Peter, Andrew Makmur, Wei Peng Yong, Jimmy B Y So

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: We evaluated the feasibility of performing CT volumetry of gastric carcinoma (GC) and its correlation with TNM stage.

Methods: This institutional review board-approved retrospective study was performed on 153 patients who underwent a staging CT study for histologically confirmed GC. CT volumetry was performed by drawing regions of interest including abnormal thickening of the stomach wall. Reproducibility of tumour volume (Tvol) between two readers was assessed. Correlation between Tvol and TNM/peritoneal staging derived from histology/surgical findings was evaluated using ROC analysis and compared with CT evaluation of TNM/peritoneal staging.

Results: Tvol was successfully performed in all patients. Reproducibility among readers was excellent (r = 0.97; P = 0.0001). The median Tvol of GC showed an incremental trend with T-stage (T1 = 27 ml; T2 = 32 ml; T3 = 53 ml and T4 = 121 ml, P < 0.01). Tvol predicted with good accuracy T-stage (≥T2:0.95; ≥T3:0.89 and T4:0.83, P = 0.0001), M-stage (0.87, P = 0.0001), peritoneal metastases (0.87, P = 0.0001) and final stage (≥stage 2:0.89; ≥stage 3:0.86 and stage 4:0.87, P = 0.0001), with moderate accuracy for N-stage (≥N1:0.75; ≥N2:0.74 and N3:0.75, P = 0.0001). Tvol was significantly (P < 0.05) more accurate than standard CT staging for prediction of T-stage, N3-stage, M-stage and peritoneal metastases.

Conclusion: CT volumetry may provide useful adjunct information for preoperative staging of GC.

Key Points: • CT volumetry of gastric carcinoma is feasible and reproducible.

• Tumour volume <19.4 ml predicts T1-stage gastric cancer with 91 % sensitivity and 100 % specificity (P = 0.0001).

• Tumour volume >95.7 ml predicts metastatic gastric cancer with 87 % sensitivity and 78.5 % specificity (P = 0.0001).

• CT volumetry may be a useful adjunct for staging gastric carcinoma.

Original languageEnglish (US)
Pages (from-to)3105-3114
Number of pages10
JournalEuropean Radiology
Volume24
Issue number12
DOIs
StatePublished - Nov 14 2014

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Stomach
Tumor Burden
Carcinoma
Neoplasm Staging
Research Ethics Committees
ROC Curve
Stomach Neoplasms
Histology
Retrospective Studies
Sensitivity and Specificity

Keywords

  • Multidetector computed tomography (MDCT)
  • Neoplasm staging
  • Stomach neoplasms
  • Tumour burden
  • Tumour volume

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Hallinan, J. T. P. D., Venkatesh, S. K., Peter, L., Makmur, A., Yong, W. P., & So, J. B. Y. (2014). CT volumetry for gastric carcinoma: association with TNM stage. European Radiology, 24(12), 3105-3114. https://doi.org/10.1007/s00330-014-3316-5

CT volumetry for gastric carcinoma : association with TNM stage. / Hallinan, James T P D; Venkatesh, Sudhakar K; Peter, Luke; Makmur, Andrew; Yong, Wei Peng; So, Jimmy B Y.

In: European Radiology, Vol. 24, No. 12, 14.11.2014, p. 3105-3114.

Research output: Contribution to journalArticle

Hallinan, JTPD, Venkatesh, SK, Peter, L, Makmur, A, Yong, WP & So, JBY 2014, 'CT volumetry for gastric carcinoma: association with TNM stage', European Radiology, vol. 24, no. 12, pp. 3105-3114. https://doi.org/10.1007/s00330-014-3316-5
Hallinan, James T P D ; Venkatesh, Sudhakar K ; Peter, Luke ; Makmur, Andrew ; Yong, Wei Peng ; So, Jimmy B Y. / CT volumetry for gastric carcinoma : association with TNM stage. In: European Radiology. 2014 ; Vol. 24, No. 12. pp. 3105-3114.
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abstract = "Objectives: We evaluated the feasibility of performing CT volumetry of gastric carcinoma (GC) and its correlation with TNM stage.Methods: This institutional review board-approved retrospective study was performed on 153 patients who underwent a staging CT study for histologically confirmed GC. CT volumetry was performed by drawing regions of interest including abnormal thickening of the stomach wall. Reproducibility of tumour volume (Tvol) between two readers was assessed. Correlation between Tvol and TNM/peritoneal staging derived from histology/surgical findings was evaluated using ROC analysis and compared with CT evaluation of TNM/peritoneal staging.Results: Tvol was successfully performed in all patients. Reproducibility among readers was excellent (r = 0.97; P = 0.0001). The median Tvol of GC showed an incremental trend with T-stage (T1 = 27 ml; T2 = 32 ml; T3 = 53 ml and T4 = 121 ml, P < 0.01). Tvol predicted with good accuracy T-stage (≥T2:0.95; ≥T3:0.89 and T4:0.83, P = 0.0001), M-stage (0.87, P = 0.0001), peritoneal metastases (0.87, P = 0.0001) and final stage (≥stage 2:0.89; ≥stage 3:0.86 and stage 4:0.87, P = 0.0001), with moderate accuracy for N-stage (≥N1:0.75; ≥N2:0.74 and N3:0.75, P = 0.0001). Tvol was significantly (P < 0.05) more accurate than standard CT staging for prediction of T-stage, N3-stage, M-stage and peritoneal metastases.Conclusion: CT volumetry may provide useful adjunct information for preoperative staging of GC.Key Points: • CT volumetry of gastric carcinoma is feasible and reproducible.• Tumour volume <19.4 ml predicts T1-stage gastric cancer with 91 {\%} sensitivity and 100 {\%} specificity (P = 0.0001).• Tumour volume >95.7 ml predicts metastatic gastric cancer with 87 {\%} sensitivity and 78.5 {\%} specificity (P = 0.0001).• CT volumetry may be a useful adjunct for staging gastric carcinoma.",
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T2 - association with TNM stage

AU - Hallinan, James T P D

AU - Venkatesh, Sudhakar K

AU - Peter, Luke

AU - Makmur, Andrew

AU - Yong, Wei Peng

AU - So, Jimmy B Y

PY - 2014/11/14

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N2 - Objectives: We evaluated the feasibility of performing CT volumetry of gastric carcinoma (GC) and its correlation with TNM stage.Methods: This institutional review board-approved retrospective study was performed on 153 patients who underwent a staging CT study for histologically confirmed GC. CT volumetry was performed by drawing regions of interest including abnormal thickening of the stomach wall. Reproducibility of tumour volume (Tvol) between two readers was assessed. Correlation between Tvol and TNM/peritoneal staging derived from histology/surgical findings was evaluated using ROC analysis and compared with CT evaluation of TNM/peritoneal staging.Results: Tvol was successfully performed in all patients. Reproducibility among readers was excellent (r = 0.97; P = 0.0001). The median Tvol of GC showed an incremental trend with T-stage (T1 = 27 ml; T2 = 32 ml; T3 = 53 ml and T4 = 121 ml, P < 0.01). Tvol predicted with good accuracy T-stage (≥T2:0.95; ≥T3:0.89 and T4:0.83, P = 0.0001), M-stage (0.87, P = 0.0001), peritoneal metastases (0.87, P = 0.0001) and final stage (≥stage 2:0.89; ≥stage 3:0.86 and stage 4:0.87, P = 0.0001), with moderate accuracy for N-stage (≥N1:0.75; ≥N2:0.74 and N3:0.75, P = 0.0001). Tvol was significantly (P < 0.05) more accurate than standard CT staging for prediction of T-stage, N3-stage, M-stage and peritoneal metastases.Conclusion: CT volumetry may provide useful adjunct information for preoperative staging of GC.Key Points: • CT volumetry of gastric carcinoma is feasible and reproducible.• Tumour volume <19.4 ml predicts T1-stage gastric cancer with 91 % sensitivity and 100 % specificity (P = 0.0001).• Tumour volume >95.7 ml predicts metastatic gastric cancer with 87 % sensitivity and 78.5 % specificity (P = 0.0001).• CT volumetry may be a useful adjunct for staging gastric carcinoma.

AB - Objectives: We evaluated the feasibility of performing CT volumetry of gastric carcinoma (GC) and its correlation with TNM stage.Methods: This institutional review board-approved retrospective study was performed on 153 patients who underwent a staging CT study for histologically confirmed GC. CT volumetry was performed by drawing regions of interest including abnormal thickening of the stomach wall. Reproducibility of tumour volume (Tvol) between two readers was assessed. Correlation between Tvol and TNM/peritoneal staging derived from histology/surgical findings was evaluated using ROC analysis and compared with CT evaluation of TNM/peritoneal staging.Results: Tvol was successfully performed in all patients. Reproducibility among readers was excellent (r = 0.97; P = 0.0001). The median Tvol of GC showed an incremental trend with T-stage (T1 = 27 ml; T2 = 32 ml; T3 = 53 ml and T4 = 121 ml, P < 0.01). Tvol predicted with good accuracy T-stage (≥T2:0.95; ≥T3:0.89 and T4:0.83, P = 0.0001), M-stage (0.87, P = 0.0001), peritoneal metastases (0.87, P = 0.0001) and final stage (≥stage 2:0.89; ≥stage 3:0.86 and stage 4:0.87, P = 0.0001), with moderate accuracy for N-stage (≥N1:0.75; ≥N2:0.74 and N3:0.75, P = 0.0001). Tvol was significantly (P < 0.05) more accurate than standard CT staging for prediction of T-stage, N3-stage, M-stage and peritoneal metastases.Conclusion: CT volumetry may provide useful adjunct information for preoperative staging of GC.Key Points: • CT volumetry of gastric carcinoma is feasible and reproducible.• Tumour volume <19.4 ml predicts T1-stage gastric cancer with 91 % sensitivity and 100 % specificity (P = 0.0001).• Tumour volume >95.7 ml predicts metastatic gastric cancer with 87 % sensitivity and 78.5 % specificity (P = 0.0001).• CT volumetry may be a useful adjunct for staging gastric carcinoma.

KW - Multidetector computed tomography (MDCT)

KW - Neoplasm staging

KW - Stomach neoplasms

KW - Tumour burden

KW - Tumour volume

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