CT image-based quantification of sub-pixel diameter microparticle accumulations in tissues using á priori biological information

Andrew J. Vercnocke, Jill L. Anderson, Steven M. Jorgensen, Erik L. Ritman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

With the increasing use of microspheres and nanoparticles for diagnostic and therapeutic purposes, the need to quantify the spatial distribution and concentration of those particles in a minimally invasive manner, such as by imaging, is required. In the case of CT-imaging, labelling of those particles with elements that have high contrast, and when possible that is specific for that element, is an obvious approach, but this still begs the question as to what extent particles that are smaller than the detector pixel can be quantified over relatively large volumes of tissue. This study is an exploration of three approaches to quantify the spatial distribution and/or size of those microscopic particles by use of; (i) a model of the impact of high contrast opaque particle on the detected x-ray attenuation, (ii) quasi-monochromatic energy CT and (iii) the statistics of random clustering of particles resulting in clusters that are larger than detector pixels and using that information to extrapolate to sub-resolution information about individual particles. To explore the role of particle size relative to detector pixel size we recorded x-ray attenuation in detector pixels smaller than the particle and then retrospectively increased the effective detector pixel size by summing the x-ray signal in contiguous pixels around the particle location.

Original languageEnglish (US)
Title of host publicationDevelopments in X-Ray Tomography IX
EditorsStuart R. Stock
PublisherSPIE
ISBN (Electronic)9781628412390
DOIs
StatePublished - Jan 1 2014
EventDevelopments in X-Ray Tomography IX - San Diego, United States
Duration: Aug 18 2014Aug 20 2014

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9212
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Other

OtherDevelopments in X-Ray Tomography IX
CountryUnited States
CitySan Diego
Period8/18/148/20/14

Keywords

  • Computed tomography
  • Detector pixel size
  • Microspheres
  • Nanoparticles
  • Particle clustering frequency
  • Particle size
  • Power law

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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