CT findings and long-term mortality after pulmonary embolism

Michael F. Morris, Bruce A. Gardner, Michael Gotway, Kristine M. Thomsen, W. Scott Harmsen, Philip A Araoz

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

OBJECTIVE. The utility of CT findings in predicting long-term mortality in patients with acute pulmonary embolism (PE) is unknown. The purpose of this study is to retrospectively determine whether three CT findings-increased embolic burden, interventricular septal bowing toward the left ventricle, and right ventricle-to-left ventricle (RV/LV) diameter ratio greater than 1-are independent predictors of long-term all-cause mortality after acute PE. MATERIALS AND METHODS. A total of 1105 patients (47% female; mean age, 63 ±16 years) with CT scans positive for PE from January 1, 1997, to December 31, 2002, were included. Scans were independently interpreted by two observers, with a third independent observer reviewing discrepant cases. CT findings and clinical information were compared with all-cause mortality using univariate and multivariate logistic regression analyses. RESULTS. The median duration of survival was 6.2 years following acute PE, with estimated 10-year survival of 37.4%. CT-derived embolic burden was associated with a very small decrease in long-term all-cause mortality in both univariate (hazard ratio [HR], 0.97; p < 0.001) and multivariate (HR, 0.97; p < 0.001) analyses. Interventricular septal bowing and RV/LV diameter ratio were not significantly associated with long-term all-cause mortality. CONCLUSION. CT findings are not predictive of decreased long-term survival after acute PE.

Original languageEnglish (US)
Pages (from-to)1346-1352
Number of pages7
JournalAmerican Journal of Roentgenology
Volume198
Issue number6
DOIs
StatePublished - Jun 2012

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Pulmonary Embolism
Heart Ventricles
Mortality
Survival
Logistic Models
Regression Analysis

Keywords

  • CT
  • Outcome
  • Pulmonary embolism
  • Survival

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

CT findings and long-term mortality after pulmonary embolism. / Morris, Michael F.; Gardner, Bruce A.; Gotway, Michael; Thomsen, Kristine M.; Harmsen, W. Scott; Araoz, Philip A.

In: American Journal of Roentgenology, Vol. 198, No. 6, 06.2012, p. 1346-1352.

Research output: Contribution to journalArticle

Morris, Michael F. ; Gardner, Bruce A. ; Gotway, Michael ; Thomsen, Kristine M. ; Harmsen, W. Scott ; Araoz, Philip A. / CT findings and long-term mortality after pulmonary embolism. In: American Journal of Roentgenology. 2012 ; Vol. 198, No. 6. pp. 1346-1352.
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