CT-definable subtypes of chronic obstructive pulmonary disease: A statement of the fleischner society<sup>1</sup>

David A. Lynch, John H M Austin, James C. Hogg, Philippe A. Grenier, Hans Ulrich Kauczor, Alexander A. Bankier, R. Graham Barr, Thomas V. Colby, Jeffrey R. Galvin, Pierre Alain Gevenois, Harvey O. Coxson, Eric A. Hoffman, John D. Newell, Massimo Pistolesi, Edwin K. Silverman, James D. Crapo

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

The purpose of this statement is to describe and define the phenotypic abnormalities that can be identified on visual and quantitative evaluation of computed tomographic (CT) images in subjects with chronic obstructive pulmonary disease (COPD), with the goal of contributing to a personalized approach to the treatment of patients with COPD. Quantitative CT is useful for identifying and sequentially evaluating the extent of emphysematous lung destruction, changes in airway walls, and expiratory air trapping. However, visual assessment of CT scans remains important to describe patterns of altered lung structure in COPD. The classification system proposed and illustrated in this article provides a structured approach to visual and quantitative assessment of COPD. Emphysema is classified as centrilobular (subclassified as trace, mild, moderate, confluent, and advanced destructive emphysema), panlobular, and paraseptal (subclassified as mild or substantial). Additional important visual features include airway wall thickening, inflammatory small airways disease, tracheal abnormalities, interstitial lung abnormalities, pulmonary arterial enlargement, and bronchiectasis.

Original languageEnglish (US)
Pages (from-to)192-205
Number of pages14
JournalRadiology
Volume277
Issue number1
DOIs
StatePublished - Oct 1 2015

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Chronic Obstructive Pulmonary Disease
Lung
Tracheal Diseases
Pulmonary Emphysema
Bronchiectasis
Emphysema
Air
Therapeutics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Lynch, D. A., Austin, J. H. M., Hogg, J. C., Grenier, P. A., Kauczor, H. U., Bankier, A. A., ... Crapo, J. D. (2015). CT-definable subtypes of chronic obstructive pulmonary disease: A statement of the fleischner society<sup>1</sup> Radiology, 277(1), 192-205. https://doi.org/10.1148/radiol.2015141579

CT-definable subtypes of chronic obstructive pulmonary disease : A statement of the fleischner society<sup>1</sup> / Lynch, David A.; Austin, John H M; Hogg, James C.; Grenier, Philippe A.; Kauczor, Hans Ulrich; Bankier, Alexander A.; Barr, R. Graham; Colby, Thomas V.; Galvin, Jeffrey R.; Gevenois, Pierre Alain; Coxson, Harvey O.; Hoffman, Eric A.; Newell, John D.; Pistolesi, Massimo; Silverman, Edwin K.; Crapo, James D.

In: Radiology, Vol. 277, No. 1, 01.10.2015, p. 192-205.

Research output: Contribution to journalArticle

Lynch, DA, Austin, JHM, Hogg, JC, Grenier, PA, Kauczor, HU, Bankier, AA, Barr, RG, Colby, TV, Galvin, JR, Gevenois, PA, Coxson, HO, Hoffman, EA, Newell, JD, Pistolesi, M, Silverman, EK & Crapo, JD 2015, 'CT-definable subtypes of chronic obstructive pulmonary disease: A statement of the fleischner society<sup>1</sup>', Radiology, vol. 277, no. 1, pp. 192-205. https://doi.org/10.1148/radiol.2015141579
Lynch, David A. ; Austin, John H M ; Hogg, James C. ; Grenier, Philippe A. ; Kauczor, Hans Ulrich ; Bankier, Alexander A. ; Barr, R. Graham ; Colby, Thomas V. ; Galvin, Jeffrey R. ; Gevenois, Pierre Alain ; Coxson, Harvey O. ; Hoffman, Eric A. ; Newell, John D. ; Pistolesi, Massimo ; Silverman, Edwin K. ; Crapo, James D. / CT-definable subtypes of chronic obstructive pulmonary disease : A statement of the fleischner society<sup>1</sup>. In: Radiology. 2015 ; Vol. 277, No. 1. pp. 192-205.
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