CSF thyrotropin-releasing hormone gender difference: Implications for neurobiology and treatment of depression

Mark A. Frye, Keith A. Gary, Lauren B. Marangell, Mark S. George, Ann M. Callahan, John T. Little, Teresa Huggins, Gabriela Corá-Locatelli, Elizabeth A. Osuch, Andrew Winokur, Robert M. Post

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

In light of the postulated role of thyrotropin-releasing hormone (TRH) as an endogenous anti-depressant, 56 refractory mood-disordered patients and 34 healthy adult control subjects underwent lumbar puncture for cerebrospinal fluid (CSF) TRH analysis. By two-way analysis of variance, there was no difference between CSF TRH in patients (as a group or by diagnostic subtype) and control subjects (n = 90, F = 0.91, df = 2,84, P = 0.41). There was, however, a CSF TRH gender difference (females, 2.95 pg/ml; males, 3.98 pg/ml; n = 90, F = 4.11, df = 1,84, P < 0.05). A post hoc t-test revealed the greatest gender difference in the bipolar group (t = 2.52, P < 0.02). There was no significant difference in CSF TRH in 'ill' vs. 'well' state (n = 20, P = 0.41). The role of elevated levels of CSF TRH in affectively ill men - or the role of decreased levels of CSF TRH in affectively ill women - remains to be investigated but could be of pathophysiological relevance.

Original languageEnglish (US)
Pages (from-to)349-353
Number of pages5
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume11
Issue number3
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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    Frye, M. A., Gary, K. A., Marangell, L. B., George, M. S., Callahan, A. M., Little, J. T., Huggins, T., Corá-Locatelli, G., Osuch, E. A., Winokur, A., & Post, R. M. (1999). CSF thyrotropin-releasing hormone gender difference: Implications for neurobiology and treatment of depression. Journal of Neuropsychiatry and Clinical Neurosciences, 11(3), 349-353. https://doi.org/10.1176/jnp.11.3.349