CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects

Michael Ewers, Philip Insel, William J. Jagust, Leslie Shaw, John Q. Trojanowski J, Paul Aisen, Ronald C. Petersen, Norbert Schuff, Michael W. Weiner

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Beta-amyloid (Aβ) is a histopathological hallmark of Alzheimer's disease dementia, but high levels of Aβ in the brain can also be found in a substantial proportion of nondemented subjects. Here we investigated which 2-year rate of brain and cognitive changes are present in nondemented subjects with high and low Aβ levels, as assessed with cerebrospinal fluid and molecular positron emission tomography (PET)-based biomarkers of Aβ. In subjects with mild cognitive impairment, increased brain Aβ levels were associated with significantly faster cognitive decline, progression of gray matter atrophy within temporal and parietal brain regions, and a trend for a faster decline in parietal Fludeoxyglucose (FDG)-PET metabolism. Changes in gray matter and FDG-PET mediated the association between Aβ and cognitive decline. In contrast, elderly cognitively healthy controls (HC) with high Aβ levels showed only a faster medial temporal lobe and precuneus volume decline compared with HC with low Aβ. In conclusion, the current results suggest not only that both functional and volumetric brain changes are associated with high Aβ years before the onset of dementia but also that HC with substantial Aβ levels show higher Aβ pathology resistance, lack other pathologies that condition neurotoxic effects of Aβ, or accumulated Aβ for a shorter time period.

Original languageEnglish (US)
Pages (from-to)1993-2004
Number of pages12
JournalCerebral Cortex
Volume22
Issue number9
DOIs
StatePublished - Sep 1 2012

Keywords

  • FDG-PET
  • MCI
  • PIB-PET

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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    Ewers, M., Insel, P., Jagust, W. J., Shaw, L., Trojanowski J, J. Q., Aisen, P., Petersen, R. C., Schuff, N., & Weiner, M. W. (2012). CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects. Cerebral Cortex, 22(9), 1993-2004. https://doi.org/10.1093/cercor/bhr271