Crystalglobulin-induced nephropathy

Vinay Gupta, Mireille El Ters, Kianoush Kashani, Nelson Leung, Samih H. Nasr

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Crystalline nephropathy refers to renal parenchymal deposition of crystals leading to kidney damage. Themost common forms of crystalline nephropathy encountered in renal pathology are nephrocalcinosis and oxalate nephropathy. Less frequent types include urate nephropathy, cystinosis, dihydroxyadeninuria, and drug-induced crystalline nephropathy (e. g., caused by indinavir or triamterene). Monoclonal proteins can also deposit in the kidney as crystals and cause tissue damage. This occurs in conditions such as light chain proximal tubulopathy, crystal-storing histiocytosis, and crystalglobulinemia. The latter is a rare complication of multiple myeloma that results from crystallization of monoclonal proteins in the systemic vasculature, leading to vascular injury, thrombosis, and occlusion. In this report, we describe a case of crystalglobulin-induced nephropathy and discuss its pathophysiology and the differential diagnosis of paraprotein-induced crystalline nephropathy.

Original languageEnglish (US)
Pages (from-to)525-529
Number of pages5
JournalJournal of the American Society of Nephrology
Volume26
Issue number3
DOIs
StatePublished - Mar 1 2015

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ASJC Scopus subject areas

  • Nephrology

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