TY - JOUR
T1 - Crystalglobulin-induced nephropathy
AU - Gupta, Vinay
AU - El Ters, Mireille
AU - Kashani, Kianoush
AU - Leung, Nelson
AU - Nasr, Samih H.
N1 - Publisher Copyright:
Copyright © 2015 by the American Society of Nephrology.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Crystalline nephropathy refers to renal parenchymal deposition of crystals leading to kidney damage. Themost common forms of crystalline nephropathy encountered in renal pathology are nephrocalcinosis and oxalate nephropathy. Less frequent types include urate nephropathy, cystinosis, dihydroxyadeninuria, and drug-induced crystalline nephropathy (e. g., caused by indinavir or triamterene). Monoclonal proteins can also deposit in the kidney as crystals and cause tissue damage. This occurs in conditions such as light chain proximal tubulopathy, crystal-storing histiocytosis, and crystalglobulinemia. The latter is a rare complication of multiple myeloma that results from crystallization of monoclonal proteins in the systemic vasculature, leading to vascular injury, thrombosis, and occlusion. In this report, we describe a case of crystalglobulin-induced nephropathy and discuss its pathophysiology and the differential diagnosis of paraprotein-induced crystalline nephropathy.
AB - Crystalline nephropathy refers to renal parenchymal deposition of crystals leading to kidney damage. Themost common forms of crystalline nephropathy encountered in renal pathology are nephrocalcinosis and oxalate nephropathy. Less frequent types include urate nephropathy, cystinosis, dihydroxyadeninuria, and drug-induced crystalline nephropathy (e. g., caused by indinavir or triamterene). Monoclonal proteins can also deposit in the kidney as crystals and cause tissue damage. This occurs in conditions such as light chain proximal tubulopathy, crystal-storing histiocytosis, and crystalglobulinemia. The latter is a rare complication of multiple myeloma that results from crystallization of monoclonal proteins in the systemic vasculature, leading to vascular injury, thrombosis, and occlusion. In this report, we describe a case of crystalglobulin-induced nephropathy and discuss its pathophysiology and the differential diagnosis of paraprotein-induced crystalline nephropathy.
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U2 - 10.1681/ASN.2014050509
DO - 10.1681/ASN.2014050509
M3 - Article
C2 - 25190731
AN - SCOPUS:84924049671
SN - 1046-6673
VL - 26
SP - 525
EP - 529
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
IS - 3
ER -