Abstract
Cryptosporidium, an intracellular parasite that infects the gastrointestinal epithelium and other mucosal surfaces, causes self-limited diarrhea in immunocompetent subjects and potentially life-threatening syndromes in immunocompromised individuals, primarily those with acquired immunodeficiency syndrome (AIDS). Cryptosporidium is also the single most common identifiable pathogen in the biliary tract in patients with AIDS-cholangiopathy, an important biliary disorder caused by opportunistic infection of the billary epithelium and resulting in significant morbidity and mortality in AIDS patients. The organism stimulates periductal inflammation in the biliary tree, induces biliary epithelial cell apoptosis, and thus contributes to the pathogenesis of AIDS-cholangiopathy. Currently, there is no fully effective medical therapy for both of the diseases. A better understanding of the parasitology of Cryptosporidium and the pathophysiology of biliary cryptosporidiosis should aid not only our understanding of the pathogenesis of AIDS-cholangiopathy but also the development of effective therapies and control of this ubiquitous, highly infectious threat.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 277-289 |
| Number of pages | 13 |
| Journal | Seminars in Liver Disease |
| Volume | 22 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 2002 |
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Keywords
- AIDS-cholangiopathy
- Bile ducts
- Cryptosporidium
- HIV
- Pathogenesis
ASJC Scopus subject areas
- Hepatology
Cite this
Cryptosporidiosis and the pathogenesis of AIDS-cholangiopathy. / Chen, Xian Ming; La Russo, Nicholas F.
In: Seminars in Liver Disease, Vol. 22, No. 3, 08.2002, p. 277-289.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cryptosporidiosis and the pathogenesis of AIDS-cholangiopathy
AU - Chen, Xian Ming
AU - La Russo, Nicholas F
PY - 2002/8
Y1 - 2002/8
N2 - Cryptosporidium, an intracellular parasite that infects the gastrointestinal epithelium and other mucosal surfaces, causes self-limited diarrhea in immunocompetent subjects and potentially life-threatening syndromes in immunocompromised individuals, primarily those with acquired immunodeficiency syndrome (AIDS). Cryptosporidium is also the single most common identifiable pathogen in the biliary tract in patients with AIDS-cholangiopathy, an important biliary disorder caused by opportunistic infection of the billary epithelium and resulting in significant morbidity and mortality in AIDS patients. The organism stimulates periductal inflammation in the biliary tree, induces biliary epithelial cell apoptosis, and thus contributes to the pathogenesis of AIDS-cholangiopathy. Currently, there is no fully effective medical therapy for both of the diseases. A better understanding of the parasitology of Cryptosporidium and the pathophysiology of biliary cryptosporidiosis should aid not only our understanding of the pathogenesis of AIDS-cholangiopathy but also the development of effective therapies and control of this ubiquitous, highly infectious threat.
AB - Cryptosporidium, an intracellular parasite that infects the gastrointestinal epithelium and other mucosal surfaces, causes self-limited diarrhea in immunocompetent subjects and potentially life-threatening syndromes in immunocompromised individuals, primarily those with acquired immunodeficiency syndrome (AIDS). Cryptosporidium is also the single most common identifiable pathogen in the biliary tract in patients with AIDS-cholangiopathy, an important biliary disorder caused by opportunistic infection of the billary epithelium and resulting in significant morbidity and mortality in AIDS patients. The organism stimulates periductal inflammation in the biliary tree, induces biliary epithelial cell apoptosis, and thus contributes to the pathogenesis of AIDS-cholangiopathy. Currently, there is no fully effective medical therapy for both of the diseases. A better understanding of the parasitology of Cryptosporidium and the pathophysiology of biliary cryptosporidiosis should aid not only our understanding of the pathogenesis of AIDS-cholangiopathy but also the development of effective therapies and control of this ubiquitous, highly infectious threat.
KW - AIDS-cholangiopathy
KW - Bile ducts
KW - Cryptosporidium
KW - HIV
KW - Pathogenesis
UR - http://www.scopus.com/inward/record.url?scp=0036698280&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036698280&partnerID=8YFLogxK
U2 - 10.1055/s-2002-34505
DO - 10.1055/s-2002-34505
M3 - Article
C2 - 12360421
AN - SCOPUS:0036698280
VL - 22
SP - 277
EP - 289
JO - Seminars in Liver Disease
JF - Seminars in Liver Disease
SN - 0272-8087
IS - 3
ER -