TY - JOUR
T1 - Cryptorchism and maternal estrogen exposure
AU - Beard, C. Mary
AU - Melton, L. Joseph
AU - O'fallon, W. Michael
AU - Noller, Kenneth L.
AU - Benson, Ralph C.
PY - 1984/11
Y1 - 1984/11
N2 - A case-control study of In utero estrogen exposure and cryptorchism was carried out using as cases males born in Rochester, Minnesota, during the years 1943-1973 who were diagnosed as having cryptorchism. Two different control groups were selected for comparison, control group I being more closely matched than control group II. The estimated relative risks (RR) for estrogen exposure were 1.3 (95% confidence interval (Cl) = 0.5-3.1) and 1.1 (95% Cl = 0.5-2.6) for control groups I and II, respectively. In the univariate analysis, the only significantly elevated relative risks found were those for bleeding and spotting in the third trimester for cases versus control group II (RR = 3.7; 95% Cl = 1.1-15.7), birth weight less than 2,500 g for cases versus controi group II (RR = 3.4; 95% Cl = 1.3-9.9), and gestational age of 40 weeks or less for cases versus control group I (RR = 1.8; 95% Cl = 1.2-2.9). No elevated relative risks were associated with other problems during the index pregnancy or with prior pregnancies, nor with progestin exposure, smoking, presentation at delivery, or mode of onset of labor. Multivarlate analysis also provided no evidence to suggest that in utero estrogen exposure is associated with cryptorchism in male offspring.
AB - A case-control study of In utero estrogen exposure and cryptorchism was carried out using as cases males born in Rochester, Minnesota, during the years 1943-1973 who were diagnosed as having cryptorchism. Two different control groups were selected for comparison, control group I being more closely matched than control group II. The estimated relative risks (RR) for estrogen exposure were 1.3 (95% confidence interval (Cl) = 0.5-3.1) and 1.1 (95% Cl = 0.5-2.6) for control groups I and II, respectively. In the univariate analysis, the only significantly elevated relative risks found were those for bleeding and spotting in the third trimester for cases versus control group II (RR = 3.7; 95% Cl = 1.1-15.7), birth weight less than 2,500 g for cases versus controi group II (RR = 3.4; 95% Cl = 1.3-9.9), and gestational age of 40 weeks or less for cases versus control group I (RR = 1.8; 95% Cl = 1.2-2.9). No elevated relative risks were associated with other problems during the index pregnancy or with prior pregnancies, nor with progestin exposure, smoking, presentation at delivery, or mode of onset of labor. Multivarlate analysis also provided no evidence to suggest that in utero estrogen exposure is associated with cryptorchism in male offspring.
KW - Cryptorchism
KW - Estrogens
KW - Progestins
KW - Retrospective studies
UR - http://www.scopus.com/inward/record.url?scp=0021676358&partnerID=8YFLogxK
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U2 - 10.1093/oxfordjournals.aje.a113938
DO - 10.1093/oxfordjournals.aje.a113938
M3 - Article
C2 - 6149686
AN - SCOPUS:0021676358
SN - 0002-9262
VL - 120
SP - 707
EP - 716
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 5
ER -