"Cryptic" dinucleotide polymorphism in the 3′ region of the factor IX gene shows substantial variation among different populations

Steve S. Sommer; Victoria L. Tillotson; Erica L. Vielhaber; Rhett P. Ketterling; Charyl M. Dutton

doi:10.1007/BF00212042

"Cryptic" dinucleotide polymorphism in the 3′ region of the factor IX gene shows substantial variation among different populations

Steve S. Sommer, Victoria L. Tillotson, Erica L. Vielhaber, Rhett P. Ketterling, Charyl M. Dutton

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Long tandem dinucleotide repeats composed of alternating purines and pyrimidines [RY(i)] are abundant and highly polymorphic. "Simple" RY(i) are predominately composed of one tandem repeat of a dinucleotide sequence. In contrast, "cryptic" RY(i [cRY(i)] are composed of multiple short dinucleotide repeats. Herein, we describe the racial distribution of alleles for a polymorphic cRY(i) in the factor IX gene. Allele I is absent in Asians, whereas allele III is rare or absent in Caucasians or blacks. A polymorphic cRY(i) analyzed previously shows even more dramatic variation among racial groups, hinting that a battery of cRY(i) might have utility in assessing the racial origin of a DNA sample.

Original language	English (US)
Pages (from-to)	357-358
Number of pages	2
Journal	Human genetics
Volume	93
Issue number	3
DOIs	https://doi.org/10.1007/BF00212042
State	Published - Mar 1994

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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@article{d7d77cd9eaf146e6ba1d37fbe5f8245e,

title = "{"}Cryptic{"} dinucleotide polymorphism in the 3′ region of the factor IX gene shows substantial variation among different populations",

abstract = "Long tandem dinucleotide repeats composed of alternating purines and pyrimidines [RY(i)] are abundant and highly polymorphic. {"}Simple{"} RY(i) are predominately composed of one tandem repeat of a dinucleotide sequence. In contrast, {"}cryptic{"} RY(i [cRY(i)] are composed of multiple short dinucleotide repeats. Herein, we describe the racial distribution of alleles for a polymorphic cRY(i) in the factor IX gene. Allele I is absent in Asians, whereas allele III is rare or absent in Caucasians or blacks. A polymorphic cRY(i) analyzed previously shows even more dramatic variation among racial groups, hinting that a battery of cRY(i) might have utility in assessing the racial origin of a DNA sample.",

author = "Sommer, {Steve S.} and Tillotson, {Victoria L.} and Vielhaber, {Erica L.} and Ketterling, {Rhett P.} and Dutton, {Charyl M.}",

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language = "English (US)",

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journal = "Human Genetics",

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T1 - "Cryptic" dinucleotide polymorphism in the 3′ region of the factor IX gene shows substantial variation among different populations

AU - Sommer, Steve S.

AU - Tillotson, Victoria L.

AU - Vielhaber, Erica L.

AU - Ketterling, Rhett P.

AU - Dutton, Charyl M.

PY - 1994/3

Y1 - 1994/3

N2 - Long tandem dinucleotide repeats composed of alternating purines and pyrimidines [RY(i)] are abundant and highly polymorphic. "Simple" RY(i) are predominately composed of one tandem repeat of a dinucleotide sequence. In contrast, "cryptic" RY(i [cRY(i)] are composed of multiple short dinucleotide repeats. Herein, we describe the racial distribution of alleles for a polymorphic cRY(i) in the factor IX gene. Allele I is absent in Asians, whereas allele III is rare or absent in Caucasians or blacks. A polymorphic cRY(i) analyzed previously shows even more dramatic variation among racial groups, hinting that a battery of cRY(i) might have utility in assessing the racial origin of a DNA sample.

AB - Long tandem dinucleotide repeats composed of alternating purines and pyrimidines [RY(i)] are abundant and highly polymorphic. "Simple" RY(i) are predominately composed of one tandem repeat of a dinucleotide sequence. In contrast, "cryptic" RY(i [cRY(i)] are composed of multiple short dinucleotide repeats. Herein, we describe the racial distribution of alleles for a polymorphic cRY(i) in the factor IX gene. Allele I is absent in Asians, whereas allele III is rare or absent in Caucasians or blacks. A polymorphic cRY(i) analyzed previously shows even more dramatic variation among racial groups, hinting that a battery of cRY(i) might have utility in assessing the racial origin of a DNA sample.

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"Cryptic" dinucleotide polymorphism in the 3′ region of the factor IX gene shows substantial variation among different populations

Abstract

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