"Cryptic" dinucleotide polymorphism in the 3′ region of the factor IX gene shows substantial variation among different populations

Steve S. Sommer, Victoria L. Tillotson, Erica L. Vielhaber, Rhett P. Ketterling, Charyl M. Dutton

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Long tandem dinucleotide repeats composed of alternating purines and pyrimidines [RY(i)] are abundant and highly polymorphic. "Simple" RY(i) are predominately composed of one tandem repeat of a dinucleotide sequence. In contrast, "cryptic" RY(i [cRY(i)] are composed of multiple short dinucleotide repeats. Herein, we describe the racial distribution of alleles for a polymorphic cRY(i) in the factor IX gene. Allele I is absent in Asians, whereas allele III is rare or absent in Caucasians or blacks. A polymorphic cRY(i) analyzed previously shows even more dramatic variation among racial groups, hinting that a battery of cRY(i) might have utility in assessing the racial origin of a DNA sample.

Original languageEnglish (US)
Pages (from-to)357-358
Number of pages2
JournalHuman genetics
Volume93
Issue number3
DOIs
StatePublished - Mar 1 1994

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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