Cryosurgery or Microsurgery in the Management of Acromegaly

Graham M. Teasdale; Ian D. Hay; Graham H. Beastall; Douglas C. Mccruden; John A. Thomson; David L. Davies; Kenneth W. Grossart; John G. Ratcliffe

doi:10.1001/jama.1982.03320340043032

Cryosurgery or Microsurgery in the Management of Acromegaly

Graham M. Teasdale, Ian D. Hay, Graham H. Beastall, Douglas C. Mccruden, John A. Thomson, David L. Davies, Kenneth W. Grossart, John G. Ratcliffe

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Fifty-six patients with growth hormone-secreting pituitary adenomas, 28 treated by cryoablation and 28 by microsurgery, have been followed up from three to eight years. Mean serum growth hormone concentrations were less than 10 mU/L in 19 patients (68%) after microsurgery as compared with seven (25%) after cryosurgery. Hypopituitarism and operative complications were more frequent after cryosurgery. Transsphenoidal microsurgery was particularly successful in reducing growth hormone secretion without impairing normal pituitary function, when the patient had not been previously treated by another method.

Original language	English (US)
Pages (from-to)	1289-1291
Number of pages	3
Journal	JAMA: The Journal of the American Medical Association
Volume	247
Issue number	9
DOIs	https://doi.org/10.1001/jama.1982.03320340043032
State	Published - Mar 5 1982

ASJC Scopus subject areas

General Medicine

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abstract = "Fifty-six patients with growth hormone-secreting pituitary adenomas, 28 treated by cryoablation and 28 by microsurgery, have been followed up from three to eight years. Mean serum growth hormone concentrations were less than 10 mU/L in 19 patients (68%) after microsurgery as compared with seven (25%) after cryosurgery. Hypopituitarism and operative complications were more frequent after cryosurgery. Transsphenoidal microsurgery was particularly successful in reducing growth hormone secretion without impairing normal pituitary function, when the patient had not been previously treated by another method.",

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AU - Hay, Ian D.

AU - Beastall, Graham H.

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AU - Thomson, John A.

AU - Davies, David L.

AU - Grossart, Kenneth W.

AU - Ratcliffe, John G.

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AB - Fifty-six patients with growth hormone-secreting pituitary adenomas, 28 treated by cryoablation and 28 by microsurgery, have been followed up from three to eight years. Mean serum growth hormone concentrations were less than 10 mU/L in 19 patients (68%) after microsurgery as compared with seven (25%) after cryosurgery. Hypopituitarism and operative complications were more frequent after cryosurgery. Transsphenoidal microsurgery was particularly successful in reducing growth hormone secretion without impairing normal pituitary function, when the patient had not been previously treated by another method.

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Cryosurgery or Microsurgery in the Management of Acromegaly

Abstract

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