Cryoglobulinemic vasculitis in a patient with CREST syndrome

Rebecca L. Hurst, Florentina Berianu, William W. Ginsburg, Christopher J. Klein, Janean K. Englestad, Kathleen D. Kennelly

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Cryoglobulinemic vasculitis is a rare entity. Although it has been reported in diffuse systemic sclerosis, it has not been reported in calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia (CREST) syndrome. We report a patient with cryoglobulinemic vasculitis with CREST syndrome who did not have typical clinical features of vasculitis. This 58-year-old woman presented with mild generalized weakness and a diagnosis of CREST syndrome, which included Raynaud's syndrome, dysphagia and telangiectasias. She was positive for serum cryoglobulins, which led to a sural nerve biopsy. The biopsy results were consistent with cryoglobulinemic vasculitis. Cryoglobulinemic vasculitis has not been previously reported in CREST syndrome to our knowledge. Additionally, the patient also had limited clinical symptoms. Our patient displays the importance of checking for cryoglobulins and obtaining a nerve biopsy when the serum is positive. Both of these diagnostic tests were integral for directing appropriate treatment for this patient.

Original languageEnglish (US)
Pages (from-to)1821-1823
Number of pages3
JournalJournal of Clinical Neuroscience
Volume21
Issue number10
DOIs
StatePublished - Oct 1 2014

Keywords

  • CREST
  • Cryoglobulinemia
  • Cryoglobulins
  • Peripheral neuropathy
  • Sural nerve biopsy
  • Systemic sclerosis
  • Vasculitis

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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