Cryoglobulinemic vasculitis in a patient with CREST syndrome

Rebecca L. Hurst, Florentina Berianu, William W. Ginsburg, Christopher Jon Klein, Janean K. Englestad, Kathleen Kennelly

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cryoglobulinemic vasculitis is a rare entity. Although it has been reported in diffuse systemic sclerosis, it has not been reported in calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia (CREST) syndrome. We report a patient with cryoglobulinemic vasculitis with CREST syndrome who did not have typical clinical features of vasculitis. This 58-year-old woman presented with mild generalized weakness and a diagnosis of CREST syndrome, which included Raynaud's syndrome, dysphagia and telangiectasias. She was positive for serum cryoglobulins, which led to a sural nerve biopsy. The biopsy results were consistent with cryoglobulinemic vasculitis. Cryoglobulinemic vasculitis has not been previously reported in CREST syndrome to our knowledge. Additionally, the patient also had limited clinical symptoms. Our patient displays the importance of checking for cryoglobulins and obtaining a nerve biopsy when the serum is positive. Both of these diagnostic tests were integral for directing appropriate treatment for this patient.

Original languageEnglish (US)
Pages (from-to)1821-1823
Number of pages3
JournalJournal of Clinical Neuroscience
Volume21
Issue number10
DOIs
StatePublished - Oct 1 2014

Fingerprint

Esophageal Motility Disorders
Calcinosis
Telangiectasis
Raynaud Disease
Vasculitis
Cryoglobulins
Biopsy
Diffuse Scleroderma
Sural Nerve
Deglutition Disorders
Serum
Routine Diagnostic Tests

Keywords

  • CREST
  • Cryoglobulinemia
  • Cryoglobulins
  • Peripheral neuropathy
  • Sural nerve biopsy
  • Systemic sclerosis
  • Vasculitis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)

Cite this

Cryoglobulinemic vasculitis in a patient with CREST syndrome. / Hurst, Rebecca L.; Berianu, Florentina; Ginsburg, William W.; Klein, Christopher Jon; Englestad, Janean K.; Kennelly, Kathleen.

In: Journal of Clinical Neuroscience, Vol. 21, No. 10, 01.10.2014, p. 1821-1823.

Research output: Contribution to journalArticle

Hurst, Rebecca L. ; Berianu, Florentina ; Ginsburg, William W. ; Klein, Christopher Jon ; Englestad, Janean K. ; Kennelly, Kathleen. / Cryoglobulinemic vasculitis in a patient with CREST syndrome. In: Journal of Clinical Neuroscience. 2014 ; Vol. 21, No. 10. pp. 1821-1823.
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