Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E

Y. Inoshima; T. Miyazawa; M. Kohmoto; Y. Ikeda; E. Sato; T. Hohdatsu; C. Mathiason-Dubard; E. A. Hoover; T. Mikami

doi:10.1007/s007050050275

Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E

Y. Inoshima, T. Miyazawa, M. Kohmoto, Y. Ikeda, E. Sato, T. Hohdatsu, C. Mathiason-Dubard, E. A. Hoover, T. Mikami

Molecular Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV genotypes A through E by sera from cats infected with a single genotype. The results indicated some relationships between phylogenetic genotype and neutralization serotype, and that cross-clade virus neutralization is possible. For example, serum from a cat infected with genotype E virus neutralized all five FIV genotypes. Our results suggest that the FIV subtyping according to the sequence diversity is partially reflected by antigenic diversity and serum neutralization.

Original language	English (US)
Pages (from-to)	157-162
Number of pages	6
Journal	Archives of Virology
Volume	143
Issue number	1
DOIs	https://doi.org/10.1007/s007050050275
State	Published - 1998

ASJC Scopus subject areas

Virology

Access to Document

10.1007/s007050050275

Cite this

@article{4b3d047c135442f9a6d8e2fe882d326c,

title = "Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E",

abstract = "Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV genotypes A through E by sera from cats infected with a single genotype. The results indicated some relationships between phylogenetic genotype and neutralization serotype, and that cross-clade virus neutralization is possible. For example, serum from a cat infected with genotype E virus neutralized all five FIV genotypes. Our results suggest that the FIV subtyping according to the sequence diversity is partially reflected by antigenic diversity and serum neutralization.",

author = "Y. Inoshima and T. Miyazawa and M. Kohmoto and Y. Ikeda and E. Sato and T. Hohdatsu and C. Mathiason-Dubard and Hoover, {E. A.} and T. Mikami",

year = "1998",

doi = "10.1007/s007050050275",

language = "English (US)",

volume = "143",

pages = "157--162",

journal = "Archives of Virology",

issn = "0304-8608",

publisher = "Springer Wien",

number = "1",

}

TY - JOUR

T1 - Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E

AU - Inoshima, Y.

AU - Miyazawa, T.

AU - Kohmoto, M.

AU - Ikeda, Y.

AU - Sato, E.

AU - Hohdatsu, T.

AU - Mathiason-Dubard, C.

AU - Hoover, E. A.

AU - Mikami, T.

PY - 1998

Y1 - 1998

N2 - Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV genotypes A through E by sera from cats infected with a single genotype. The results indicated some relationships between phylogenetic genotype and neutralization serotype, and that cross-clade virus neutralization is possible. For example, serum from a cat infected with genotype E virus neutralized all five FIV genotypes. Our results suggest that the FIV subtyping according to the sequence diversity is partially reflected by antigenic diversity and serum neutralization.

AB - Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV genotypes A through E by sera from cats infected with a single genotype. The results indicated some relationships between phylogenetic genotype and neutralization serotype, and that cross-clade virus neutralization is possible. For example, serum from a cat infected with genotype E virus neutralized all five FIV genotypes. Our results suggest that the FIV subtyping according to the sequence diversity is partially reflected by antigenic diversity and serum neutralization.

UR - http://www.scopus.com/inward/record.url?scp=0031885071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031885071&partnerID=8YFLogxK

U2 - 10.1007/s007050050275

DO - 10.1007/s007050050275

M3 - Article

C2 - 9505973

AN - SCOPUS:0031885071

SN - 0304-8608

VL - 143

SP - 157

EP - 162

JO - Archives of Virology

JF - Archives of Virology

IS - 1

ER -

Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this