TY - JOUR
T1 - Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E
AU - Inoshima, Y.
AU - Miyazawa, T.
AU - Kohmoto, M.
AU - Ikeda, Y.
AU - Sato, E.
AU - Hohdatsu, T.
AU - Mathiason-Dubard, C.
AU - Hoover, E. A.
AU - Mikami, T.
PY - 1998
Y1 - 1998
N2 - Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV genotypes A through E by sera from cats infected with a single genotype. The results indicated some relationships between phylogenetic genotype and neutralization serotype, and that cross-clade virus neutralization is possible. For example, serum from a cat infected with genotype E virus neutralized all five FIV genotypes. Our results suggest that the FIV subtyping according to the sequence diversity is partially reflected by antigenic diversity and serum neutralization.
AB - Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV genotypes A through E by sera from cats infected with a single genotype. The results indicated some relationships between phylogenetic genotype and neutralization serotype, and that cross-clade virus neutralization is possible. For example, serum from a cat infected with genotype E virus neutralized all five FIV genotypes. Our results suggest that the FIV subtyping according to the sequence diversity is partially reflected by antigenic diversity and serum neutralization.
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U2 - 10.1007/s007050050275
DO - 10.1007/s007050050275
M3 - Article
C2 - 9505973
AN - SCOPUS:0031885071
SN - 0304-8608
VL - 143
SP - 157
EP - 162
JO - Archives of Virology
JF - Archives of Virology
IS - 1
ER -