Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E

Y. Inoshima, T. Miyazawa, M. Kohmoto, Y. Ikeda, E. Sato, T. Hohdatsu, C. Mathiason-Dubard, E. A. Hoover, T. Mikami

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV genotypes A through E by sera from cats infected with a single genotype. The results indicated some relationships between phylogenetic genotype and neutralization serotype, and that cross-clade virus neutralization is possible. For example, serum from a cat infected with genotype E virus neutralized all five FIV genotypes. Our results suggest that the FIV subtyping according to the sequence diversity is partially reflected by antigenic diversity and serum neutralization.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalArchives of Virology
Volume143
Issue number1
DOIs
StatePublished - Mar 27 1998

ASJC Scopus subject areas

  • Virology

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