Cross-validation of magnetic resonance elastography and ultrasound-based transient elastography: A preliminary phantom study

Jennifer Oudry, Jun Chen, Kevin J. Glaser, Véronique Miette, Laurent Sandrin, Richard L. Ehman

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Purpose: To cross-validate two recent noninvasive elastographic techniques, ultrasound-based transient elastography (UTE) and magnetic resonance elastography (MRE). As potential alternatives to liver biopsy, UTE and MRE are undergoing clinical investigations for liver fibrosis diagnosis and liver disease management around the world. These two techniques use tissue stiffness as a marker for disease state and it is important to do a cross-validation study of both elastographic techniques to determine the consistency with which the two techniques can measure the mechanical properties of materials. Materials and Methods: In this study, 19 well-characterized phantoms with a range of stiffness values were measured by two clinical devices (a Fibroscan and an MRE system based respectively on the UTE and MRE techniques) successively with the operators double-blinded. Results: Statistical analysis showed that the correlation coefficient was r2 = 0.93 between MRE and UTE, and there was no evidence of a systematic difference between them within the range of stiffnesses examined. Conclusion: These two noninvasive methods, MRE and UTE, provide clinicians with important new options for improving patient care regarding liver diseases in terms of the diagnosis, prognosis, and monitoring of fibrosis progression, as well for evaluating the efficacy of treatment.

Original languageEnglish (US)
Pages (from-to)1145-1150
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume30
Issue number5
DOIs
StatePublished - Nov 2009

Keywords

  • Cross-validation
  • Elastography
  • Fibrosis diagnosis
  • Magnetic resonance elastography
  • Phantoms
  • Ultrasound-based elastography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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