Cross-reactivity patterns of influenza-specific cytotoxic T lymphocytes from H-2Kb mutant mice

J. L. Hurwitz, P. J. Wettstein, J. R. Bennink, P. C. Doherty

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3 Scopus citations

Abstract

Limit dilution cultures were used to test for influenza immune T cell populations from bm1 and bm3 mutant mice that were not lytic for virus-infected targets expressing the Kb and Db major histocompatibility complex glycoproteins. Both K(bm1- and K(bm1-restricted cytotoxic T cells were detected. Such effectors showed minimal cross-recognition of influenza on other mutant targets, except for the case of bm1 and bm10 targets. This is dissimilar to previous findings concerning vaccinia presentation in which bm3+bm11, bm1+bm9, and bm3+bm9 pairs each showed high cross-reactivity. These differences illustrate the role of the H-2K glycoprotein in immune responsiveness. Not only are multiple determinants on each H-2K glycoprotein involved in antigen presentation, they appear to play differential roles in the presentation of different viral antigens.

Original languageEnglish (US)
Pages (from-to)471-474
Number of pages4
JournalJournal of Immunology
Volume131
Issue number1
StatePublished - 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Hurwitz, J. L., Wettstein, P. J., Bennink, J. R., & Doherty, P. C. (1983). Cross-reactivity patterns of influenza-specific cytotoxic T lymphocytes from H-2Kb mutant mice. Journal of Immunology, 131(1), 471-474.