Cross-reactivity patterns of influenza-specific cytotoxic T lymphocytes from H-2Kb mutant mice

J. L. Hurwitz, P. J. Wettstein, J. R. Bennink, P. C. Doherty

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Limit dilution cultures were used to test for influenza immune T cell populations from bm1 and bm3 mutant mice that were not lytic for virus-infected targets expressing the Kb and Db major histocompatibility complex glycoproteins. Both K(bm1- and K(bm1-restricted cytotoxic T cells were detected. Such effectors showed minimal cross-recognition of influenza on other mutant targets, except for the case of bm1 and bm10 targets. This is dissimilar to previous findings concerning vaccinia presentation in which bm3+bm11, bm1+bm9, and bm3+bm9 pairs each showed high cross-reactivity. These differences illustrate the role of the H-2K glycoprotein in immune responsiveness. Not only are multiple determinants on each H-2K glycoprotein involved in antigen presentation, they appear to play differential roles in the presentation of different viral antigens.

Original languageEnglish (US)
Pages (from-to)471-474
Number of pages4
JournalJournal of Immunology
Volume131
Issue number1
StatePublished - 1983
Externally publishedYes

Fingerprint

Cytotoxic T-Lymphocytes
Human Influenza
Glycoproteins
T-Lymphocytes
Vaccinia
Viral Antigens
Antigen Presentation
Major Histocompatibility Complex
Viruses
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Hurwitz, J. L., Wettstein, P. J., Bennink, J. R., & Doherty, P. C. (1983). Cross-reactivity patterns of influenza-specific cytotoxic T lymphocytes from H-2Kb mutant mice. Journal of Immunology, 131(1), 471-474.

Cross-reactivity patterns of influenza-specific cytotoxic T lymphocytes from H-2Kb mutant mice. / Hurwitz, J. L.; Wettstein, P. J.; Bennink, J. R.; Doherty, P. C.

In: Journal of Immunology, Vol. 131, No. 1, 1983, p. 471-474.

Research output: Contribution to journalArticle

Hurwitz, JL, Wettstein, PJ, Bennink, JR & Doherty, PC 1983, 'Cross-reactivity patterns of influenza-specific cytotoxic T lymphocytes from H-2Kb mutant mice', Journal of Immunology, vol. 131, no. 1, pp. 471-474.
Hurwitz, J. L. ; Wettstein, P. J. ; Bennink, J. R. ; Doherty, P. C. / Cross-reactivity patterns of influenza-specific cytotoxic T lymphocytes from H-2Kb mutant mice. In: Journal of Immunology. 1983 ; Vol. 131, No. 1. pp. 471-474.
@article{2b4d16738745402aa829550b03ea9be7,
title = "Cross-reactivity patterns of influenza-specific cytotoxic T lymphocytes from H-2Kb mutant mice",
abstract = "Limit dilution cultures were used to test for influenza immune T cell populations from bm1 and bm3 mutant mice that were not lytic for virus-infected targets expressing the Kb and Db major histocompatibility complex glycoproteins. Both K(bm1- and K(bm1-restricted cytotoxic T cells were detected. Such effectors showed minimal cross-recognition of influenza on other mutant targets, except for the case of bm1 and bm10 targets. This is dissimilar to previous findings concerning vaccinia presentation in which bm3+bm11, bm1+bm9, and bm3+bm9 pairs each showed high cross-reactivity. These differences illustrate the role of the H-2K glycoprotein in immune responsiveness. Not only are multiple determinants on each H-2K glycoprotein involved in antigen presentation, they appear to play differential roles in the presentation of different viral antigens.",
author = "Hurwitz, {J. L.} and Wettstein, {P. J.} and Bennink, {J. R.} and Doherty, {P. C.}",
year = "1983",
language = "English (US)",
volume = "131",
pages = "471--474",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "1",

}

TY - JOUR

T1 - Cross-reactivity patterns of influenza-specific cytotoxic T lymphocytes from H-2Kb mutant mice

AU - Hurwitz, J. L.

AU - Wettstein, P. J.

AU - Bennink, J. R.

AU - Doherty, P. C.

PY - 1983

Y1 - 1983

N2 - Limit dilution cultures were used to test for influenza immune T cell populations from bm1 and bm3 mutant mice that were not lytic for virus-infected targets expressing the Kb and Db major histocompatibility complex glycoproteins. Both K(bm1- and K(bm1-restricted cytotoxic T cells were detected. Such effectors showed minimal cross-recognition of influenza on other mutant targets, except for the case of bm1 and bm10 targets. This is dissimilar to previous findings concerning vaccinia presentation in which bm3+bm11, bm1+bm9, and bm3+bm9 pairs each showed high cross-reactivity. These differences illustrate the role of the H-2K glycoprotein in immune responsiveness. Not only are multiple determinants on each H-2K glycoprotein involved in antigen presentation, they appear to play differential roles in the presentation of different viral antigens.

AB - Limit dilution cultures were used to test for influenza immune T cell populations from bm1 and bm3 mutant mice that were not lytic for virus-infected targets expressing the Kb and Db major histocompatibility complex glycoproteins. Both K(bm1- and K(bm1-restricted cytotoxic T cells were detected. Such effectors showed minimal cross-recognition of influenza on other mutant targets, except for the case of bm1 and bm10 targets. This is dissimilar to previous findings concerning vaccinia presentation in which bm3+bm11, bm1+bm9, and bm3+bm9 pairs each showed high cross-reactivity. These differences illustrate the role of the H-2K glycoprotein in immune responsiveness. Not only are multiple determinants on each H-2K glycoprotein involved in antigen presentation, they appear to play differential roles in the presentation of different viral antigens.

UR - http://www.scopus.com/inward/record.url?scp=0020525154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020525154&partnerID=8YFLogxK

M3 - Article

VL - 131

SP - 471

EP - 474

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 1

ER -