Cross correlation–based misregistration correction for super resolution T2-weighted spin-echo images: application to prostate

Eric A. Borisch, Roger C. Grimm, Soudabeh Kargar, Akira Kawashima, Phillip J. Rossman, Stephen J. Riederer

Research output: Contribution to journalArticlepeer-review


Purpose: The purpose is to develop a retrospective correction for subtle slice-to-slice positional inconsistencies that can occur when overlapped slices are acquired for super resolution in T2-weighted spin-echo multislice imaging. Methods: Spin-echo acquisition of overlapped slices is typically done using multiple passes. After the passes are assembled into the final slice set, consecutive slices are correlated due to their overlap. Cross correlation was used to measure slice-to-slice displacement. After Z-dependent filtering to preserve true object shape, the displacements were used to correct slice position. The method was tested in a phantom moved slowly (0.16-0.63 mm/pass) under computer control and in vivo in 16 patients having prostate MRI. Results: Over the motion range, the correlation method had an accuracy within 0.03 mm/pass and precision ± 0.20 mm (ie, subpixel). Corrected images visually resemble the true object. Over the patient studies, the mean range of motion in the anterior–posterior direction was 1.63 mm. Motion-corrected axial images and the sagittal reformats were evaluated as significantly superior over those formed without motion correction. Conclusion: The retrospective correlation-based motion-correction method provides significant improvement in the slice-to-slice registration necessary for effective super resolution using overlapped slices.

Original languageEnglish (US)
Pages (from-to)1350-1363
Number of pages14
JournalMagnetic Resonance in Medicine
Issue number3
StatePublished - Mar 2021


  • T2-weighted spin echo
  • misregistration artifact
  • motion correction
  • prostate MRI
  • through-plane super resolution

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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