Crohn's Disease. Genetics Update

Ming Hsi Wang, Michael F. Picco

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Since the discovery of the first Crohn's disease (CD) gene NOD2 in 2001, 140 genetic loci have been found in whites using high-throughput genome-wide association studies. Several genes influence CD subphenotypes and treatment response. With the observations of increasing prevalence in Asia and developing countries and the incomplete explanation of CD variance, other underexplored areas need to be integrated through novel methodologies. Algorithms that incorporate specific genetic risk alleles with other biomarkers will be developed and used to predict CD disease course, complications, and response to specific therapies, allowing precision medicine to become real in CD.

Original languageEnglish (US)
JournalGastroenterology Clinics of North America
DOIs
StateAccepted/In press - 2017

Keywords

  • Behavior
  • Crohn's disease
  • Genetic score
  • Genetics
  • GWAS
  • NOD2
  • Phenotypes
  • TNF

ASJC Scopus subject areas

  • Gastroenterology

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