Crohn's Disease: Genetics Update

Ming Hsi Wang, Michael F. Picco

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Since the discovery of the first Crohn's disease (CD) gene NOD2 in 2001, 140 genetic loci have been found in whites using high-throughput genome-wide association studies. Several genes influence the CD subphenotypes and treatment response. With the observations of increasing prevalence in Asia and developing countries and the incomplete explanation of CD variance, other underexplored areas need to be integrated through novel methodologies. Algorithms that incorporate specific genetic risk alleles with other biomarkers will be developed and used to predict CD disease course, complications, and response to specific therapies, allowing precision medicine to become real in CD.

Original languageEnglish (US)
Pages (from-to)449-461
Number of pages13
JournalGastroenterology Clinics of North America
Volume46
Issue number3
DOIs
StatePublished - Sep 2017

Keywords

  • Behavior
  • Crohn's disease
  • GWAS
  • Genetic score
  • Genetics
  • NOD2
  • Phenotypes
  • TNF

ASJC Scopus subject areas

  • Gastroenterology

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