Crescentic glomerulonephritis and dense deposit disease in a woman with breast carcinoma on immunosuppressive chemotherapy

Sanjeev Sethi, Mandeep Sahani, Liem Som Oei, Radha Rao

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The authors describe an unusual case of acute renal failure in a 50-year-old woman with a history of breast carcinoma. The breast carcinoma was treated with 4 cycles of chemotherapy. After chemotherapy, she felt fatigued and noticed decreased urine output. Her serum creatinine level had risen from 0.8 to 10.1 mg/dL (71 to 893 μmol/L). Renal biopsy was done that showed a severe crescentic glomerulonephritis secondary to dense deposit disease. This case is extremely unusual in that: (1) Dense deposit disease developed in a 50-year-old woman, whereas it is primarily a disease of children and young adults, and (2) the patient was being treated with immunosuppressive chemotherapy for breast carcinoma when dense deposit disease developed, thus posing a therapeutic dilemma.

Original languageEnglish (US)
Pages (from-to)e33-e37
JournalAmerican Journal of Kidney Diseases
Volume44
Issue number3
DOIs
StatePublished - Sep 1 2004

Keywords

  • Dense deposit disease
  • breast carcinoma
  • crescentic glomerulonephritis

ASJC Scopus subject areas

  • Nephrology

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