Creation of sidewall aneurysm in rabbits: Aneurysm patency and growth follow-up

Yong Hong Ding, Tai Tieu, David F. Kallmes

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Introduction: To explore the patency and growth of surgical sidewall aneurysms in rabbits. Materials and methods: Forty sidewall aneurysms were created in the right common carotid artery (RCCA). Intravenous digital subtraction angiography (DSA) through the ear vein was performed immediately after creation. Three weeks later, intra-arterial DSA through the femoral artery was performed. Aneurysm sizes (neck, width, height and volume) were measured and calculated immediately after creation and 3 weeks later. Aneurysm patency after creation was evaluated. Differences in aneurysm sizes immediately after creation and 3 weeks later were compared using the Student's t test. Results: Aneurysms and the parent artery remained patent in 38 (95%) of the 40 rabbits 3 weeks after creation. Two other rabbits (5%) showed aneurysm occlusion. There was a significant difference in aneurysm neck size 3 weeks after creation (3.6±0.9 mm vs 2.4±0.4 mm, p<0.0001). The aneurysm became wider 3 weeks later (5.8±1.5 mm vs 4.3±1.2 mm, p<0.0001). Aneurysm length was also larger than immediately after creation (6.1±1.3 mm vs 4.3±1.4 mm, p<0.0001). The aneurysm volume was larger than that created immediately (127.5±89.4 mm3 vs 51.0±34.9 mm3, p<0.0001). Conclusions: The patency rate of sidewall aneurysms in rabbits is high. The aneurysm keeps growing for at least 3 weeks after creation.

Original languageEnglish (US)
Pages (from-to)29-31
Number of pages3
JournalJournal of neurointerventional surgery
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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