Coxsackievirus-induced myocarditis in mice: A model of autoimmune disease for studying immunotoxicity

DeLisa Fairweather, Noel R. Rose

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Excellent animal models are available for virus-induced and autoimmune heart disease that are remarkably similar to human disease. Developing good animal models for heart disease is crucial because cardiovascular disease is now the leading cause of death in the United States and is estimated to be the leading cause of death in the world by the year 2020. A significant proportion of heart disease in Western populations is associated with inflammation. Myocarditis, or inflammation of the heart muscle, is the major cause of sudden death in young adults. Although most individuals recover from acute myocarditis, genetically susceptible individuals may go on to develop chronic myocarditis and dilated cardiomyopathy (DCM) resulting in congestive heart failure. In this article, we describe a model of autoimmune myocarditis and DCM induced by inoculation with heart-passaged coxsackievirus B3 (CVB3). Intraperitoneal inoculation of susceptible mice with CVB3 induces acute cardiac inflammation from days 7 to 14 postinfection (pi) that progresses to chronic myocarditis and DCM from day 28 to at least 56 pi. The model of CVB3-induced myocarditis presented here allows dissection of the contribution of viral infection and xenobiotics on immune dysregulation and inflammation in the heart. An improved understanding of the interaction between environmental exposures and the development of heart disease represents a clear challenge for immunotoxicologists.

Original languageEnglish (US)
Pages (from-to)118-122
Number of pages5
JournalMethods
Volume41
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

Fingerprint

Enterovirus
Myocarditis
Autoimmune Diseases
Heart Diseases
Dilated Cardiomyopathy
Inflammation
Cause of Death
Animal Models
Animals
Environmental Exposure
Xenobiotics
Virus Diseases
Sudden Death
Dissection
Young Adult
Myocardium
Cardiovascular Diseases
Heart Failure
Viruses
Muscle

Keywords

  • Animal model
  • Autoimmunity
  • Coxsackievirus
  • Immunotoxicology
  • Myocarditis

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Coxsackievirus-induced myocarditis in mice : A model of autoimmune disease for studying immunotoxicity. / Fairweather, DeLisa; Rose, Noel R.

In: Methods, Vol. 41, No. 1, 01.2007, p. 118-122.

Research output: Contribution to journalArticle

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