Could HLA-DRB1 be the protective locus in rheumatoid arthritis?

Eric Zanelli, Miguel A. Gonzalez-Gay, Chella S. David

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

Extensive studies in different ethnic groups have associated the susceptibility to development of rheumatoid arthritis (RA) with the third hypervariable region of the major histocompatibility complex (MHC) HLA-DRβl molecule. On the basis of recent findings in the experimental mouse model of collagen-induced arthritis. Eric Zanelli, Miguel Gonzalez-Gay and Chella David propose that the HLA-DRB1 locus is associated with protection to RA and that the actual arthritogenic peptide-presenting molecule is HLA-DQ. Thus, the development of RA would depend upon the expression of the susceptible DQ allele and the nonprotective DRB1 alleles, along with environmental factors that trigger the autoimmune process.

Original languageEnglish (US)
Pages (from-to)274-278
Number of pages5
JournalImmunology Today
Volume16
Issue number6
DOIs
StatePublished - 1995

Fingerprint

HLA-DRB1 Chains
Rheumatoid Arthritis
Alleles
HLA-DQ Antigens
Experimental Arthritis
Major Histocompatibility Complex
Ethnic Groups
Theoretical Models
Peptides

ASJC Scopus subject areas

  • Immunology

Cite this

Could HLA-DRB1 be the protective locus in rheumatoid arthritis? / Zanelli, Eric; Gonzalez-Gay, Miguel A.; David, Chella S.

In: Immunology Today, Vol. 16, No. 6, 1995, p. 274-278.

Research output: Contribution to journalArticle

Zanelli, E, Gonzalez-Gay, MA & David, CS 1995, 'Could HLA-DRB1 be the protective locus in rheumatoid arthritis?', Immunology Today, vol. 16, no. 6, pp. 274-278. https://doi.org/10.1016/0167-5699(95)80181-2
Zanelli, Eric ; Gonzalez-Gay, Miguel A. ; David, Chella S. / Could HLA-DRB1 be the protective locus in rheumatoid arthritis?. In: Immunology Today. 1995 ; Vol. 16, No. 6. pp. 274-278.
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