Costs of venous thromboembolism associated with hospitalization for medical illness

Kevin P. Cohoon, Cynthia L. Leibson, Jeanine E. Ransom, Aneel Arjun Ashrani, Tanya M. Petterson, Kirsten Hall Long, Kent R Bailey, Johm A. Heit

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

OBJECTIVES: To determine population-based estimates of medical costs attributable to venous thromboembolism (VTE) among patients currently or recently hospitalized for acute medical illness.

STUDY DESIGN: Population-based cohort study conducted in Olmsted County, Minnesota.

METHODS: Using Rochester Epidemiology Project (REP) resources, we identified all Olmsted County residents with objectively diagnosed incident VTE during or within 92 days of hospitalization for acute medical illness over the 18-year period of 1988 to 2005 (n=286). One Olmsted County resident hospitalized for medical illness without VTE was matched to each case for event date (±1 year), duration of prior medical history, and active cancer status. Subjects were followed forward in REP provider-linked billing data for standardized, inflation-adjusted direct medical costs (excluding outpatient pharmaceutical costs) from 1 year before their respective event or index date to the earliest of death, emigration from Olmsted County, or December 31, 2011 (study end date). We censored follow-up such that each case and matched control had similar periods of observation. We used generalized linear modeling (controlling for age, sex, preexisting conditions, and costs 1 year before index) to predict costs for cases and controls.

RESULTS: Adjusted mean predicted costs were 2.5-fold higher for cases ($62,838) than for controls ($24,464) (P<.001) from index to up to 5 years post index. Cost differences between cases and controls were greatest within the first 3 months after the event date (mean difference=$16,897) but costs remained significantly higher for cases compared with controls for up to 3 years.

CONCLUSIONS: VTE during or after recent hospitalization for medical illness contributes a substantial economic burden.

Original languageEnglish (US)
Pages (from-to)e255-e263
JournalThe American journal of managed care
Volume21
Issue number4
StatePublished - Apr 1 2015

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Venous Thromboembolism
Hospitalization
Costs and Cost Analysis
Epidemiology
Preexisting Condition Coverage
Cost Control
Emigration and Immigration
Economic Inflation
Population
Cohort Studies
Outpatients
Economics
Observation
Pharmaceutical Preparations
Neoplasms

ASJC Scopus subject areas

  • Health Policy

Cite this

Cohoon, K. P., Leibson, C. L., Ransom, J. E., Ashrani, A. A., Petterson, T. M., Long, K. H., ... Heit, J. A. (2015). Costs of venous thromboembolism associated with hospitalization for medical illness. The American journal of managed care, 21(4), e255-e263.

Costs of venous thromboembolism associated with hospitalization for medical illness. / Cohoon, Kevin P.; Leibson, Cynthia L.; Ransom, Jeanine E.; Ashrani, Aneel Arjun; Petterson, Tanya M.; Long, Kirsten Hall; Bailey, Kent R; Heit, Johm A.

In: The American journal of managed care, Vol. 21, No. 4, 01.04.2015, p. e255-e263.

Research output: Contribution to journalArticle

Cohoon, KP, Leibson, CL, Ransom, JE, Ashrani, AA, Petterson, TM, Long, KH, Bailey, KR & Heit, JA 2015, 'Costs of venous thromboembolism associated with hospitalization for medical illness', The American journal of managed care, vol. 21, no. 4, pp. e255-e263.
Cohoon KP, Leibson CL, Ransom JE, Ashrani AA, Petterson TM, Long KH et al. Costs of venous thromboembolism associated with hospitalization for medical illness. The American journal of managed care. 2015 Apr 1;21(4):e255-e263.
Cohoon, Kevin P. ; Leibson, Cynthia L. ; Ransom, Jeanine E. ; Ashrani, Aneel Arjun ; Petterson, Tanya M. ; Long, Kirsten Hall ; Bailey, Kent R ; Heit, Johm A. / Costs of venous thromboembolism associated with hospitalization for medical illness. In: The American journal of managed care. 2015 ; Vol. 21, No. 4. pp. e255-e263.
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AU - Petterson, Tanya M.

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N2 - OBJECTIVES: To determine population-based estimates of medical costs attributable to venous thromboembolism (VTE) among patients currently or recently hospitalized for acute medical illness.STUDY DESIGN: Population-based cohort study conducted in Olmsted County, Minnesota.METHODS: Using Rochester Epidemiology Project (REP) resources, we identified all Olmsted County residents with objectively diagnosed incident VTE during or within 92 days of hospitalization for acute medical illness over the 18-year period of 1988 to 2005 (n=286). One Olmsted County resident hospitalized for medical illness without VTE was matched to each case for event date (±1 year), duration of prior medical history, and active cancer status. Subjects were followed forward in REP provider-linked billing data for standardized, inflation-adjusted direct medical costs (excluding outpatient pharmaceutical costs) from 1 year before their respective event or index date to the earliest of death, emigration from Olmsted County, or December 31, 2011 (study end date). We censored follow-up such that each case and matched control had similar periods of observation. We used generalized linear modeling (controlling for age, sex, preexisting conditions, and costs 1 year before index) to predict costs for cases and controls.RESULTS: Adjusted mean predicted costs were 2.5-fold higher for cases ($62,838) than for controls ($24,464) (P<.001) from index to up to 5 years post index. Cost differences between cases and controls were greatest within the first 3 months after the event date (mean difference=$16,897) but costs remained significantly higher for cases compared with controls for up to 3 years.CONCLUSIONS: VTE during or after recent hospitalization for medical illness contributes a substantial economic burden.

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