Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS

S. Wang, G. Zhu, A. I. Chapoval, H. Dong, K. Tamada, J. Ni, L. Chen

Research output: Contribution to journalArticle

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Abstract

This report describes a new human B7-like gene designated B7-H2. Cell surface expression of B7-H2 protein is detected in monocyte-derived immature dendritic cells. Soluble B7-H2 and immunoglobulin (Ig) fusion protein, B7-H2Ig, binds activated but not resting T cells and the binding is abrogated by inducible costimulator Ig (ICOSIg), but not CTLA4Ig. In addition, ICOSIg stains Chinese hamster ovary cells transfected with B7-H2 gene. By suboptimal cross-linking of CD3, costimulation of T-cell proliferation by B7-H2Ig is dose-dependent and correlates with secretion of interleukin (IL)-2, whereas optimal CD3 ligation preferentially stimulates IL-10 production. The results indicate that B7-H2 is a putative ligand for the ICOS T-cell molecule. (C) 2000 by The American Society of Hematology.

Original languageEnglish (US)
Pages (from-to)2808-2813
Number of pages6
JournalBlood
Volume96
Issue number8
StatePublished - Oct 15 2000

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ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Wang, S., Zhu, G., Chapoval, A. I., Dong, H., Tamada, K., Ni, J., & Chen, L. (2000). Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood, 96(8), 2808-2813.