Cost-effectiveness of Pancreatic Cancer Surveillance in High-Risk Individuals: An Economic Analysis

Juan E. Corral, Ananya Das, Marco J. Bruno, Michael B. Wallace

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objective The aim of the study was to perform an economic analysis to identify the clinical and cost determinants of pancreatic cancer (PC) surveillance in high-risk individuals (HRIs). Methods A Markov model was created to compare the following 3 strategies: no screening, endoscopic ultrasound (EUS), and magnetic resonance imaging (MRI) screening. Patients were considered HRIs according to the Cancer of the Pancreas Screening consortium recommendations. Risk for developing PC, survival, and costs data were obtained from the Surveillance, Epidemiology, and End Results and Medicare databases. Surveillance effectiveness was obtained from a recent meta-analysis. Results Analysis of a cohort with fivefold relative risk of PC higher than the US population showed that MRI is the most cost-effective strategy. For those with the highest risk (>×20 relative risk), EUS became the dominant strategy. Our model was impacted by cost and imaging performance, but still cost-effective within the range reported in literature. Threshold analysis showed that if MRI increases greater than US $1600, EUS becomes more cost-effective. Once patients reached the age of 76 years, "no screening" was favored. Both surveillance strategies were cost-effective over a wide range of willingness to pay. Conclusions Abdominal imaging followed by pancreatectomy is cost-effective to prevent PC in HRIs, favoring MRI in moderate risk cases but EUS in those with highest risk.

Original languageEnglish (US)
Pages (from-to)526-536
Number of pages11
JournalPancreas
Volume48
Issue number4
DOIs
StatePublished - Apr 1 2019

Keywords

  • Abbreviations
  • CMS-Center for Medicare Services
  • DM-Diabetes mell
  • EUS-Endoscopic ultrasound
  • FNA-Fine needle aspiration
  • FPC-Familial pancreatic cancer
  • HP-Hereditary pancreatitis
  • HRI-High risk individuals
  • ICER-Incremental cost-effectiveness ratio
  • INHB-Incremental net health benefit
  • MRI-Magnetic resonance imaging
  • NHB-Net health benefit
  • PJS-Peutz-Jeghers syndrome
  • QALY-Quality adjusted life years
  • RR-Relative risk
  • SEER-National Cancer Institute-Surveillance, epidemiology, and end results program
  • abdominal imaging
  • high-risk individuals
  • pancreatic cancer
  • screening
  • surveillance

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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