Corticotropin releasing factor antagonist reduces ischemic hippocampal neuronal injury

Mark K. Lyons, Robert E. Anderson, Fredric B. Meyer

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

This experimented tested the hypothesis that corticotropin-releasing factor (CRF) contributes to hippocampal ischemic injury. The antagonist to CRF (α-CRF) was administered intraventriculary 15 min prior to 10 min of transient forebrain ischemia in the Wistar rat. α-CRF demontrated a neuroprotective effect in a dose-dependent manner most notable in CA1. There was also an increase in postischemic EEG recovery. It is postulated that CRF contributes to hippocampal ischemic injury through increased neuronal activity.

Original languageEnglish (US)
Pages (from-to)339-342
Number of pages4
JournalBrain Research
Volume545
Issue number1-2
DOIs
StatePublished - Apr 5 1991

Keywords

  • Antagonist
  • Corticotropin-releasing factor
  • Electroencephalogram
  • Hippocampus
  • Ischemia
  • Neuron

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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