Corticotropin releasing factor antagonist reduces ischemic hippocampal neuronal injury

Mark K. Lyons; Robert E. Anderson; Fredric B. Meyer

doi:10.1016/0006-8993(91)91310-W

Corticotropin releasing factor antagonist reduces ischemic hippocampal neuronal injury

Mark K. Lyons, Robert E. Anderson, Fredric B. Meyer

Neurosurgery

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

This experimented tested the hypothesis that corticotropin-releasing factor (CRF) contributes to hippocampal ischemic injury. The antagonist to CRF (α-CRF) was administered intraventriculary 15 min prior to 10 min of transient forebrain ischemia in the Wistar rat. α-CRF demontrated a neuroprotective effect in a dose-dependent manner most notable in CA1. There was also an increase in postischemic EEG recovery. It is postulated that CRF contributes to hippocampal ischemic injury through increased neuronal activity.

Original language	English (US)
Pages (from-to)	339-342
Number of pages	4
Journal	Brain Research
Volume	545
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(91)91310-W
State	Published - Apr 5 1991

Keywords

Antagonist
Corticotropin-releasing factor
Electroencephalogram
Hippocampus
Ischemia
Neuron

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(91)91310-W

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title = "Corticotropin releasing factor antagonist reduces ischemic hippocampal neuronal injury",

abstract = "This experimented tested the hypothesis that corticotropin-releasing factor (CRF) contributes to hippocampal ischemic injury. The antagonist to CRF (α-CRF) was administered intraventriculary 15 min prior to 10 min of transient forebrain ischemia in the Wistar rat. α-CRF demontrated a neuroprotective effect in a dose-dependent manner most notable in CA1. There was also an increase in postischemic EEG recovery. It is postulated that CRF contributes to hippocampal ischemic injury through increased neuronal activity.",

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AU - Anderson, Robert E.

AU - Meyer, Fredric B.

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N2 - This experimented tested the hypothesis that corticotropin-releasing factor (CRF) contributes to hippocampal ischemic injury. The antagonist to CRF (α-CRF) was administered intraventriculary 15 min prior to 10 min of transient forebrain ischemia in the Wistar rat. α-CRF demontrated a neuroprotective effect in a dose-dependent manner most notable in CA1. There was also an increase in postischemic EEG recovery. It is postulated that CRF contributes to hippocampal ischemic injury through increased neuronal activity.

AB - This experimented tested the hypothesis that corticotropin-releasing factor (CRF) contributes to hippocampal ischemic injury. The antagonist to CRF (α-CRF) was administered intraventriculary 15 min prior to 10 min of transient forebrain ischemia in the Wistar rat. α-CRF demontrated a neuroprotective effect in a dose-dependent manner most notable in CA1. There was also an increase in postischemic EEG recovery. It is postulated that CRF contributes to hippocampal ischemic injury through increased neuronal activity.

KW - Antagonist

KW - Corticotropin-releasing factor

KW - Electroencephalogram

KW - Hippocampus

KW - Ischemia

KW - Neuron

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ER -

Corticotropin releasing factor antagonist reduces ischemic hippocampal neuronal injury

Abstract

Keywords

ASJC Scopus subject areas

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