@inbook{cb0b30baca114d61b032d6995c40f964,
title = "Corticobasal degeneration",
abstract = "Corticobasal degeneration (CBD) is a rare neurodegenerative disease characterized by the predominance of pathological 4 repeat tau deposition in various cell types and anatomical regions. Corticobasal syndrome (CBS) is one of the clinical phenotypes associated with CBD pathology, manifesting as a progressive asymmetric akinetic-rigid, poorly levodopa-responsive parkinsonism, with cerebral cortical dysfunction. CBD can manifest as several clinical phenotypes, and similarly, CBS can also have a pathologic diagnosis other than CBD. This chapter discusses the clinical manifestations of pathologically confirmed CBD cases, the current diagnostic criteria, as well as the pathologic and neuroimaging findings of CBD/CBS. At present, therapeutic options for CBD remain symptomatic. Further research is needed to improve the clinical diagnosis of CBD, as well as studies on disease-modifying therapies for this relentlessly progressive neurodegenerative disorder.",
keywords = "4R-tauopathy, Atypical parkinsonism, Corticobasal degeneration, Corticobasal syndrome, Tauopathy",
author = "Saranza, {Gerard M.} and Whitwell, {Jennifer L.} and Kovacs, {Gabor G.} and Lang, {Anthony E.}",
note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
doi = "10.1016/bs.irn.2019.10.014",
language = "English (US)",
isbn = "9780128177303",
series = "International Review of Neurobiology",
publisher = "Academic Press Inc",
pages = "87--136",
editor = "Maria Stamelou and H{\"o}glinger, {G{\"u}nter U.}",
booktitle = "Parkinsonism Beyond Parkinson's Disease",
}