Corrigendum to “Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's disease” [EBioMedicine 2 (2015) 294–305] (Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease (2015) 2(4) (294–305), (S2352396415000729), (10.1016/j.ebiom.2015.03.009))

Liang Zhang, Song Zhang, Izumi Maezawa, Sergey Trushin, Paras Minhas, Matthew Pinto, Lee Way Jin, Keshar Prasain, Thi D.T. Nguyen, Yu Yamazaki, Takahisa Kanekiyo, Guojun D Bu, Benjamin Gateno, Kyeong Ok Chang, Karl A Nath, Emirhan Nemutlu, Petras P Dzeja, Yuan-Ping Pang, Duy H. Hua, Eugenia D Trushina

Research output: Contribution to journalComment/debate

Abstract

In the version of this article originally published, in Supplementary Tables 1 and 2 CP2 concentrations were incorrectly presented in μM instead of nM. Tables are included here to reflect correct values including additional data for independent concentration evaluation. The mistake was introduced due to an error in the concentration of the standard used for the HPLC quantification. Additionally, in the Results section, the sentence “Average concentration of CP2 in the brain of new-born mice was ~90 μM, and in adult mice ~130 μM …” should be replaced with: “Average concentration of CP2 in the brain of new-born mice was ~90 nM, and in adult mice ~130 nM …”. Since CP2 was used as a model compound for a proof of concept studies, this mistake will not impact any preclinical developments.

Original languageEnglish (US)
Number of pages1
JournalEBioMedicine
Volume42
DOIs
StatePublished - Apr 1 2019

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Brain
Alzheimer Disease
Animals
Animal Models
Modulation
High Pressure Liquid Chromatography
corrigendum
Cognitive Dysfunction
Alzheimer disease type 2

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{2c98de63318f43b99d59c505787c7fe9,
title = "Corrigendum to “Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's disease” [EBioMedicine 2 (2015) 294–305] (Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease (2015) 2(4) (294–305), (S2352396415000729), (10.1016/j.ebiom.2015.03.009))",
abstract = "In the version of this article originally published, in Supplementary Tables 1 and 2 CP2 concentrations were incorrectly presented in μM instead of nM. Tables are included here to reflect correct values including additional data for independent concentration evaluation. The mistake was introduced due to an error in the concentration of the standard used for the HPLC quantification. Additionally, in the Results section, the sentence “Average concentration of CP2 in the brain of new-born mice was ~90 μM, and in adult mice ~130 μM …” should be replaced with: “Average concentration of CP2 in the brain of new-born mice was ~90 nM, and in adult mice ~130 nM …”. Since CP2 was used as a model compound for a proof of concept studies, this mistake will not impact any preclinical developments.",
author = "Liang Zhang and Song Zhang and Izumi Maezawa and Sergey Trushin and Paras Minhas and Matthew Pinto and Jin, {Lee Way} and Keshar Prasain and Nguyen, {Thi D.T.} and Yu Yamazaki and Takahisa Kanekiyo and Bu, {Guojun D} and Benjamin Gateno and Chang, {Kyeong Ok} and Nath, {Karl A} and Emirhan Nemutlu and Dzeja, {Petras P} and Yuan-Ping Pang and Hua, {Duy H.} and Trushina, {Eugenia D}",
year = "2019",
month = "4",
day = "1",
doi = "10.1016/j.ebiom.2019.03.062",
language = "English (US)",
volume = "42",
journal = "EBioMedicine",
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TY - JOUR

T1 - Corrigendum to “Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's disease” [EBioMedicine 2 (2015) 294–305] (Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease (2015) 2(4) (294–305), (S2352396415000729), (10.1016/j.ebiom.2015.03.009))

AU - Zhang, Liang

AU - Zhang, Song

AU - Maezawa, Izumi

AU - Trushin, Sergey

AU - Minhas, Paras

AU - Pinto, Matthew

AU - Jin, Lee Way

AU - Prasain, Keshar

AU - Nguyen, Thi D.T.

AU - Yamazaki, Yu

AU - Kanekiyo, Takahisa

AU - Bu, Guojun D

AU - Gateno, Benjamin

AU - Chang, Kyeong Ok

AU - Nath, Karl A

AU - Nemutlu, Emirhan

AU - Dzeja, Petras P

AU - Pang, Yuan-Ping

AU - Hua, Duy H.

AU - Trushina, Eugenia D

PY - 2019/4/1

Y1 - 2019/4/1

N2 - In the version of this article originally published, in Supplementary Tables 1 and 2 CP2 concentrations were incorrectly presented in μM instead of nM. Tables are included here to reflect correct values including additional data for independent concentration evaluation. The mistake was introduced due to an error in the concentration of the standard used for the HPLC quantification. Additionally, in the Results section, the sentence “Average concentration of CP2 in the brain of new-born mice was ~90 μM, and in adult mice ~130 μM …” should be replaced with: “Average concentration of CP2 in the brain of new-born mice was ~90 nM, and in adult mice ~130 nM …”. Since CP2 was used as a model compound for a proof of concept studies, this mistake will not impact any preclinical developments.

AB - In the version of this article originally published, in Supplementary Tables 1 and 2 CP2 concentrations were incorrectly presented in μM instead of nM. Tables are included here to reflect correct values including additional data for independent concentration evaluation. The mistake was introduced due to an error in the concentration of the standard used for the HPLC quantification. Additionally, in the Results section, the sentence “Average concentration of CP2 in the brain of new-born mice was ~90 μM, and in adult mice ~130 μM …” should be replaced with: “Average concentration of CP2 in the brain of new-born mice was ~90 nM, and in adult mice ~130 nM …”. Since CP2 was used as a model compound for a proof of concept studies, this mistake will not impact any preclinical developments.

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