Corrigendum to “Blockade of vascular endothelial growth factor receptor-1 (Flt-1), reveals a novel analgesic for osteoarthritis-induced joint pain” (Gene Reports (2018) 11 (94–100), (S2452014418300244) (10.1016/j.genrep.2018.03.008))

As the principal investigator and senior author for the above-mentioned publication (Das et al., 2018, GENE REPORTS 11, 94–100), it has been brought to my attention that a portion of 2.4. Surgical procedure for OA induction in the Materials and Methods section in this publication contains inaccurate description. Hence, we are respectfully requesting to publish a corrigendum to replace the surgical procedure with proper description and references as below: 2.4 Surgical procedure for OA induction All the surgical operations were performed under a microscope in an aseptic setting. Mice were placed in a supine position and anesthetized with 1.5% isoflurane (Abbott Laboratories, North Chicago, IL, USA) in oxygen via a facemask at a rate of 1 L/min. The toe or tail pinch with toothed forceps was used to assess the depth of anesthesia, and flick responses were interpreted as inadequate anesthesia. After confirming adequate anesthesia, a 1 cm left knee incision was made with a #15 scalpel blade. The knee joint was identified from the tibia and femur; and the medial meniscotibial ligament was identified using anatomic landmarks. To induce partial medial meniscectomy (PMM), which destabilizes the ligaments, a microscalpel at a depth of 0.5 mm was used to remove meniscus at midline (Knights et al., 2012; Kroin; et al., 2016; Das et al., 2018). The skin incision will be then closed with 4-0 vicryl suture. Below two references need to be added: (i) Kroin, J.S., Kc, R., Li, X., Hamilton, J.L., Das, V., van Wijnen, A.J., Dall O.M., Shelly, D.A., Kenworth T., Im, H.J. (2016). Intraarticular slow-release triamcinolone acetate reduces allodynia in an experimental mouse knee osteoarthritis model. Gene 591, 1–5. doi: https://doi.org/10.1016/j.gene.2016.06.049. Epub 2016 Jun 26.(ii) Knights C.B., Gentry C., Bevan S. (2012). Partial medial meniscectomy produces osteoarthritis pain-related behavior in female C57BL/6/mice. Pain 2012, 153, 281–292. doi: https://doi.org/10.1016/j.pain.2011.09.007. Epub 2011 Oct 15.(iii) Das V, Kc R, Li X, Varma D, Qiu S, Kroin JS, Forsyth CB, Keshavarzian A, van Wijnen AJ, Park TJ, Stein GS, O-Sullivan I, Burris TP, Im HJ. (2018). Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain. Gene 655, 1–12. doi: https://doi.org/10.1016/j.gene.2018.02.048. Epub 2018 Feb 20.The authors would like to apologise for any inconvenience caused.