@article{e5596f5a8e464f41b73af448689642c2,
title = "Correlations of apathy and depression with postural instability in Parkinson disease",
abstract = "Background Postural instability (PI) in Parkinson's disease (PD) is associated with depression and apathy based on UPDRS scores. We sought to examine the link using more objective PI measures. Methods Demographic, clinical, depression and apathy data were recorded for PD patients prospectively recruited from an outpatient university movement disorders clinic. PI was objectively evaluated using the standing center of pressure sway area. Results Thirty-seven PD patients participated in the study. Bivariate analysis revealed that PI was significantly correlated to both apathy (p = 0.018) and depression (p = 0.014). Hierarchical regression revealed that apathy significantly predicted PI but depression did not significantly add to the prediction. Also, depression did not significantly predict PI and the addition of apathy did not increase this prediction. Conclusion Apathy and depression are both associated with objective measures of PI, and apathy appears a stronger predictor of PI than depression. Concomitant improvement in PI may be important to consider when measuring apathy or depression interventions in PD.",
keywords = "Affect, Gait, Mood, Parkinsonism, Posturography, Rating scales",
author = "Anhar Hassan and Srikant Vallabhajosula and Zahodne, {Laura B.} and Dawn Bowers and Okun, {Michael S.} and Fernandez, {Hubert H.} and Hass, {Chris J.}",
note = "Funding Information: The authors declare that they have no conflicts of interest to disclose for this work. For the full financial disclosure of the previous 12 months, Dr. Hassan, Dr Vallabhajosula, Dr. Zahodne, Dr. Bowers and Dr. Hass declare that they have no conflicts of interest to disclose. Dr. Okun has received support from the National Parkinson Foundation, the National Institute of Health, the Michael J. Fox Foundation, and the Parkinson Alliance; performed CME for PeerView, Prime, CSF, and Vanderbilt. Dr. Fernandez has received research support from Abbott, Acadia, Biotie Therapeutics, EMD-Serono, the Huntington Study Group, Ipsen, Merz Pharmaceuticals, the Michael J. Fox Foundation, the Movement Disorders Society, the National Parkinson Foundation, the NINDS of the NIH, Novartis, the Parkinson Study Group, and Teva; honoraria from the University of South Florida Continuing Medical Education (CME), the Cleveland Clinic CME, Medical Communications Media, Health Professions Conferencing, Ipsen, Merz Pharmaceuticals, and the US World Meds; and royalty payments from Demos Publishing, Manson Publishing, and Springer Publishing; he is also a consultant for Merz Pharmaceuticals, Ipsen Pharmaceuticals, and United Biosource Corporation and received a stipend from the Movement Disorders Society for serving as the medical editor of the Movement Disorders Society website.",
year = "2014",
month = mar,
day = "15",
doi = "10.1016/j.jns.2013.12.040",
language = "English (US)",
volume = "338",
pages = "162--165",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",
}