Correlations between measles, mumps, and rubella serum antibody levels in Olmsted County school children

Jennifer L. St. Sauver; Robert M. Jacobson; Robert A. Vierkant; Steven J. Jacobsen; Erin M. Green; Daniel J. Schaid; Gregory A. Poland

doi:10.1016/S0264-410X(00)00376-5

Correlations between measles, mumps, and rubella serum antibody levels in Olmsted County school children

Jennifer L. St. Sauver, Robert M. Jacobson, Robert A. Vierkant, Steven J. Jacobsen, Erin M. Green, Daniel J. Schaid, Gregory A. Poland

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We examined correlations between serum antibody levels to determine whether individuals with low levels of antibody to one component of the measles, mumps, and rubella (MMR) vaccine were also likely to have low antibody levels to the other MMR vaccine components. Our results indicate that children who had a low antibody level to one component of the MMR vaccine had a modest probability of having a low antibody level to either of the other MMR vaccine components. Overall, we found small, but statistically significant, correlations between antibody levels that were largely unaffected by race, sex, age at immunization, and time since immunization. While the correlations we observed were modest, ∼25% of our population was seronegative for at least one component of the MMR vaccine. Therefore, our results support the current policy of continuing to administer the trivalent MMR vaccine even when only a single low antibody titer is observed.

Original language	English (US)
Pages (from-to)	1363-1368
Number of pages	6
Journal	Vaccine
Volume	19
Issue number	11-12
DOIs	https://doi.org/10.1016/S0264-410X(00)00376-5
State	Published - Jan 8 2001

Keywords

Antibodies
Measles vaccine
Mumps vaccine
Rubella vaccine

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(00)00376-5

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title = "Correlations between measles, mumps, and rubella serum antibody levels in Olmsted County school children",

abstract = "We examined correlations between serum antibody levels to determine whether individuals with low levels of antibody to one component of the measles, mumps, and rubella (MMR) vaccine were also likely to have low antibody levels to the other MMR vaccine components. Our results indicate that children who had a low antibody level to one component of the MMR vaccine had a modest probability of having a low antibody level to either of the other MMR vaccine components. Overall, we found small, but statistically significant, correlations between antibody levels that were largely unaffected by race, sex, age at immunization, and time since immunization. While the correlations we observed were modest, ∼25% of our population was seronegative for at least one component of the MMR vaccine. Therefore, our results support the current policy of continuing to administer the trivalent MMR vaccine even when only a single low antibody titer is observed.",

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AU - St. Sauver, Jennifer L.

AU - Jacobson, Robert M.

AU - Vierkant, Robert A.

AU - Jacobsen, Steven J.

AU - Green, Erin M.

AU - Schaid, Daniel J.

AU - Poland, Gregory A.

PY - 2001/1/8

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N2 - We examined correlations between serum antibody levels to determine whether individuals with low levels of antibody to one component of the measles, mumps, and rubella (MMR) vaccine were also likely to have low antibody levels to the other MMR vaccine components. Our results indicate that children who had a low antibody level to one component of the MMR vaccine had a modest probability of having a low antibody level to either of the other MMR vaccine components. Overall, we found small, but statistically significant, correlations between antibody levels that were largely unaffected by race, sex, age at immunization, and time since immunization. While the correlations we observed were modest, ∼25% of our population was seronegative for at least one component of the MMR vaccine. Therefore, our results support the current policy of continuing to administer the trivalent MMR vaccine even when only a single low antibody titer is observed.

AB - We examined correlations between serum antibody levels to determine whether individuals with low levels of antibody to one component of the measles, mumps, and rubella (MMR) vaccine were also likely to have low antibody levels to the other MMR vaccine components. Our results indicate that children who had a low antibody level to one component of the MMR vaccine had a modest probability of having a low antibody level to either of the other MMR vaccine components. Overall, we found small, but statistically significant, correlations between antibody levels that were largely unaffected by race, sex, age at immunization, and time since immunization. While the correlations we observed were modest, ∼25% of our population was seronegative for at least one component of the MMR vaccine. Therefore, our results support the current policy of continuing to administer the trivalent MMR vaccine even when only a single low antibody titer is observed.

KW - Antibodies

KW - Measles vaccine

KW - Mumps vaccine

KW - Rubella vaccine

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Correlations between measles, mumps, and rubella serum antibody levels in Olmsted County school children

Abstract

Keywords

ASJC Scopus subject areas

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