TY - JOUR
T1 - Correlation of TGF-(si expression with medroxiprogesterone acetate responsiveness in mouse mammary adenocarcinomas
AU - Elizalde, Patricia V.
AU - Guerra, Fabiana K.
AU - Gravano, Martin
AU - Lanari, Claudia
AU - Lippman, Marc E.
AU - Charreau, Eduardo H.
AU - Lupu, Ruth
PY - 1995/1/1
Y1 - 1995/1/1
N2 - We investigated the expression of transforming growth factors β1 and α (TGF-β1, TGF-α in hormone-responsive (MPA-R) and unresponsive (MPA-U) tumor lines obtained from medroxyprogesterone acetate (MPA)-induced mammary adenocarcinomas in BALBIc mice. The tumors were transplanted into MPA-treated and untreated mice. TGF-β1 gene expression was observed in the MPA-R lines growing in untreated animals, but not in MPA-treated mice. TGF-β1 mRNA was not detected in the MPA-U tumor lines growing in either MPA-treated or untreated animals. In MPA-R lines the levels of TGF-β1 expression were inversely correlated to growth rate. High-affinity TGF-β1 receptors were present in the MPA-R tumors. These results suggest that one of the mechanisms by which MP A exerts its proliferative effect on MPA-R tumor lines is inhibition of the expression of TGF-β1. Thus, the lack of expression of TGF-β1 in MPA-U tumors may be related to the acquisition of autonomous growth.
AB - We investigated the expression of transforming growth factors β1 and α (TGF-β1, TGF-α in hormone-responsive (MPA-R) and unresponsive (MPA-U) tumor lines obtained from medroxyprogesterone acetate (MPA)-induced mammary adenocarcinomas in BALBIc mice. The tumors were transplanted into MPA-treated and untreated mice. TGF-β1 gene expression was observed in the MPA-R lines growing in untreated animals, but not in MPA-treated mice. TGF-β1 mRNA was not detected in the MPA-U tumor lines growing in either MPA-treated or untreated animals. In MPA-R lines the levels of TGF-β1 expression were inversely correlated to growth rate. High-affinity TGF-β1 receptors were present in the MPA-R tumors. These results suggest that one of the mechanisms by which MP A exerts its proliferative effect on MPA-R tumor lines is inhibition of the expression of TGF-β1. Thus, the lack of expression of TGF-β1 in MPA-U tumors may be related to the acquisition of autonomous growth.
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U2 - 10.3109/07357909509011687
DO - 10.3109/07357909509011687
M3 - Article
C2 - 7874571
AN - SCOPUS:0028927483
VL - 13
SP - 173
EP - 180
JO - Cancer Investigation
JF - Cancer Investigation
SN - 0735-7907
IS - 2
ER -