Correlation of staging systems to survival in patients with resected hilar cholangiocarcinoma

Victor M. Zaydfudim, Clancy J. Clark, Michael L. Kendrick, Florencia G. Que, Kaye M. Reid-Lombardo, John H. Donohue, Michael B. Farnell, David M. Nagorney

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Background: We aimed to identify staging parameters associated with survival in patients with hilar cholangiocarcinoma. Methods: Clinicopathologic characteristics were obtained retrospectively for all resected patients with Bismuth-Corlette III cholangiocarcinoma between 1993 and 2011. Patients were stratified by the American Joint Commission on Cancer (AJCC) (7th edition) and Memorial Sloan-Kettering Cancer Center (MSKCC) staging systems. Survival analyses tested the effects of clinicopathologic factors and staging covariates on recurrence-free and overall survival. Results: Eighty patients (mean age 63 ± 11 years, 63% male) underwent anatomic hepatectomy with bile duct resection/reconstruction for Bismuth-Corlette IIIa (53%) and IIIb (47%) cholangiocarcinoma. The median follow-up was 26 months (interquartile range = 12 to 50 months), and the median time to recurrence was 15 months (interquartile range = 6 to 38 months). Neither AJCC nor MSKCC staging systems were associated with recurrence-free survival (all P ≥.059). MSKCC T-stage but not the AJCC staging system was associated with overall survival (P ≤.026). Conclusions: MSKCC T-stage classification but not AJCC staging is independently associated with overall survival for patients after resection of hilar cholangiocarcinoma.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalAmerican journal of surgery
Issue number2
StatePublished - Aug 2013


  • American Joint Commission on Cancer stage
  • Bismuth-Corlette
  • Hilar cholangiocarcinoma
  • Memorial Sloan-Kettering Cancer Center stage
  • Survival

ASJC Scopus subject areas

  • Surgery


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