Correlation of regional emphysema and lung cancer: A lung tissue research consortium-based study

Laurie A. Hohberger, Darrell R. Schroeder, Brian Jack Bartholmai, Ping Yang, Christine H. Wendt, Peter B. Bitterman, Ola Larsson, Andrew Harold Limper

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

BACKGROUND:: Chronic obstructive pulmonary disease and lung cancer are linked because both airflow obstruction and emphysema, on computer tomography, are independent risk factors for lung cancer. However, the local risk of malignancy relative to development of regional emphysema has not yet been defined. Specifically, it is not known if primary lung cancers are associated with regions of worse emphysema within individual patients. METHODS:: We performed a database analysis evaluating the association between the degree of regional emphysema as scored on computer tomography and development of primary lung cancer. We also studied the association between regional emphysema and benign lung nodules. We assembled two distinct cohorts using the National Heart, Lung, and Blood Institute's Lung Tissue Research Consortium database, hypothesizing that lung malignancy will preferentially locate in the regions of the most severe emphysema. RESULTS:: In the Lung Tissue Research Consortium database, 624 cases met criteria for the malignant nodule cohort and 64 were included in the benign nodule cohort. When comparing location of a malignant nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of lung cancer was 1.342 (95% confidence interval 1.112-1.620; p = 0.0022). When comparing location of a benign nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of the benign nodule was 1.118 (95% confidence interval 0.725-1.725; p = 0.6137). CONCLUSIONS:: Primary lung cancers are associated with areas of worse regional emphysema.

Original languageEnglish (US)
Pages (from-to)639-645
Number of pages7
JournalJournal of Thoracic Oncology
Volume9
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Emphysema
Lung Neoplasms
Research
Lung
Databases
Tomography
Confidence Intervals
National Heart, Lung, and Blood Institute (U.S.)
Chronic Obstructive Pulmonary Disease
Neoplasms

Keywords

  • Computerized tomography
  • COPD
  • Emphysema
  • Lung cancer

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Correlation of regional emphysema and lung cancer : A lung tissue research consortium-based study. / Hohberger, Laurie A.; Schroeder, Darrell R.; Bartholmai, Brian Jack; Yang, Ping; Wendt, Christine H.; Bitterman, Peter B.; Larsson, Ola; Limper, Andrew Harold.

In: Journal of Thoracic Oncology, Vol. 9, No. 5, 2014, p. 639-645.

Research output: Contribution to journalArticle

Hohberger, Laurie A. ; Schroeder, Darrell R. ; Bartholmai, Brian Jack ; Yang, Ping ; Wendt, Christine H. ; Bitterman, Peter B. ; Larsson, Ola ; Limper, Andrew Harold. / Correlation of regional emphysema and lung cancer : A lung tissue research consortium-based study. In: Journal of Thoracic Oncology. 2014 ; Vol. 9, No. 5. pp. 639-645.
@article{16d3ada15a4541a5936d3f361fbd4097,
title = "Correlation of regional emphysema and lung cancer: A lung tissue research consortium-based study",
abstract = "BACKGROUND:: Chronic obstructive pulmonary disease and lung cancer are linked because both airflow obstruction and emphysema, on computer tomography, are independent risk factors for lung cancer. However, the local risk of malignancy relative to development of regional emphysema has not yet been defined. Specifically, it is not known if primary lung cancers are associated with regions of worse emphysema within individual patients. METHODS:: We performed a database analysis evaluating the association between the degree of regional emphysema as scored on computer tomography and development of primary lung cancer. We also studied the association between regional emphysema and benign lung nodules. We assembled two distinct cohorts using the National Heart, Lung, and Blood Institute's Lung Tissue Research Consortium database, hypothesizing that lung malignancy will preferentially locate in the regions of the most severe emphysema. RESULTS:: In the Lung Tissue Research Consortium database, 624 cases met criteria for the malignant nodule cohort and 64 were included in the benign nodule cohort. When comparing location of a malignant nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of lung cancer was 1.342 (95{\%} confidence interval 1.112-1.620; p = 0.0022). When comparing location of a benign nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of the benign nodule was 1.118 (95{\%} confidence interval 0.725-1.725; p = 0.6137). CONCLUSIONS:: Primary lung cancers are associated with areas of worse regional emphysema.",
keywords = "Computerized tomography, COPD, Emphysema, Lung cancer",
author = "Hohberger, {Laurie A.} and Schroeder, {Darrell R.} and Bartholmai, {Brian Jack} and Ping Yang and Wendt, {Christine H.} and Bitterman, {Peter B.} and Ola Larsson and Limper, {Andrew Harold}",
year = "2014",
doi = "10.1097/JTO.0000000000000144",
language = "English (US)",
volume = "9",
pages = "639--645",
journal = "Journal of Thoracic Oncology",
issn = "1556-0864",
publisher = "International Association for the Study of Lung Cancer",
number = "5",

}

TY - JOUR

T1 - Correlation of regional emphysema and lung cancer

T2 - A lung tissue research consortium-based study

AU - Hohberger, Laurie A.

AU - Schroeder, Darrell R.

AU - Bartholmai, Brian Jack

AU - Yang, Ping

AU - Wendt, Christine H.

AU - Bitterman, Peter B.

AU - Larsson, Ola

AU - Limper, Andrew Harold

PY - 2014

Y1 - 2014

N2 - BACKGROUND:: Chronic obstructive pulmonary disease and lung cancer are linked because both airflow obstruction and emphysema, on computer tomography, are independent risk factors for lung cancer. However, the local risk of malignancy relative to development of regional emphysema has not yet been defined. Specifically, it is not known if primary lung cancers are associated with regions of worse emphysema within individual patients. METHODS:: We performed a database analysis evaluating the association between the degree of regional emphysema as scored on computer tomography and development of primary lung cancer. We also studied the association between regional emphysema and benign lung nodules. We assembled two distinct cohorts using the National Heart, Lung, and Blood Institute's Lung Tissue Research Consortium database, hypothesizing that lung malignancy will preferentially locate in the regions of the most severe emphysema. RESULTS:: In the Lung Tissue Research Consortium database, 624 cases met criteria for the malignant nodule cohort and 64 were included in the benign nodule cohort. When comparing location of a malignant nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of lung cancer was 1.342 (95% confidence interval 1.112-1.620; p = 0.0022). When comparing location of a benign nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of the benign nodule was 1.118 (95% confidence interval 0.725-1.725; p = 0.6137). CONCLUSIONS:: Primary lung cancers are associated with areas of worse regional emphysema.

AB - BACKGROUND:: Chronic obstructive pulmonary disease and lung cancer are linked because both airflow obstruction and emphysema, on computer tomography, are independent risk factors for lung cancer. However, the local risk of malignancy relative to development of regional emphysema has not yet been defined. Specifically, it is not known if primary lung cancers are associated with regions of worse emphysema within individual patients. METHODS:: We performed a database analysis evaluating the association between the degree of regional emphysema as scored on computer tomography and development of primary lung cancer. We also studied the association between regional emphysema and benign lung nodules. We assembled two distinct cohorts using the National Heart, Lung, and Blood Institute's Lung Tissue Research Consortium database, hypothesizing that lung malignancy will preferentially locate in the regions of the most severe emphysema. RESULTS:: In the Lung Tissue Research Consortium database, 624 cases met criteria for the malignant nodule cohort and 64 were included in the benign nodule cohort. When comparing location of a malignant nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of lung cancer was 1.342 (95% confidence interval 1.112-1.620; p = 0.0022). When comparing location of a benign nodule to other lung regions within the same person, the odds of having a more severe emphysema score in the location of the benign nodule was 1.118 (95% confidence interval 0.725-1.725; p = 0.6137). CONCLUSIONS:: Primary lung cancers are associated with areas of worse regional emphysema.

KW - Computerized tomography

KW - COPD

KW - Emphysema

KW - Lung cancer

UR - http://www.scopus.com/inward/record.url?scp=84899480336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899480336&partnerID=8YFLogxK

U2 - 10.1097/JTO.0000000000000144

DO - 10.1097/JTO.0000000000000144

M3 - Article

C2 - 24662456

AN - SCOPUS:84899480336

VL - 9

SP - 639

EP - 645

JO - Journal of Thoracic Oncology

JF - Journal of Thoracic Oncology

SN - 1556-0864

IS - 5

ER -