Correlation of erythrocyte catechol-O-methyltransferase activity between siblings

Richard M. Weinshilboum; Fredrick A. Raymond; Lila R. Elveback; William H. Weidman

doi:10.1038/252490a0

Correlation of erythrocyte catechol-O-methyltransferase activity between siblings

Richard M. Weinshilboum, Fredrick A. Raymond, Lila R. Elveback, William H. Weidman

Pharmacology

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38 Scopus citations

Abstract

CATECHOL-O-METHYLTRANSFERASE (COMT) is the enzyme that catalyses the conversion of noradrenaline, adrenaline, dopamine, and other catechol compounds to their O-methylated metabolites¹. COMT is widely distributed in many tissues including the red blood cell (RBC)^1,2 and individual differences in the activity of this enzyme in human beings may be involved in the pathogenesis of various psychiatric and neurological diseases^3,4. Inhibitors of COMT have been used experimentally in the treatment of Parkinson's disease and other neurological diseases⁵. COMT activity is decreased in red blood cells obtained from depressed women³ and is increased in erythrocytes obtained from children with Down's syndrome ⁶.

Original language	English (US)
Pages (from-to)	490-491
Number of pages	2
Journal	Nature
Volume	252
Issue number	5483
DOIs	https://doi.org/10.1038/252490a0
State	Published - 1974

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title = "Correlation of erythrocyte catechol-O-methyltransferase activity between siblings",

abstract = "CATECHOL-O-METHYLTRANSFERASE (COMT) is the enzyme that catalyses the conversion of noradrenaline, adrenaline, dopamine, and other catechol compounds to their O-methylated metabolites1. COMT is widely distributed in many tissues including the red blood cell (RBC)1,2 and individual differences in the activity of this enzyme in human beings may be involved in the pathogenesis of various psychiatric and neurological diseases3,4. Inhibitors of COMT have been used experimentally in the treatment of Parkinson's disease and other neurological diseases5. COMT activity is decreased in red blood cells obtained from depressed women3 and is increased in erythrocytes obtained from children with Down's syndrome 6.",

author = "Weinshilboum, {Richard M.} and Raymond, {Fredrick A.} and Elveback, {Lila R.} and Weidman, {William H.}",

year = "1974",

doi = "10.1038/252490a0",

language = "English (US)",

volume = "252",

pages = "490--491",

journal = "Nature",

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T1 - Correlation of erythrocyte catechol-O-methyltransferase activity between siblings

AU - Weinshilboum, Richard M.

AU - Raymond, Fredrick A.

AU - Elveback, Lila R.

AU - Weidman, William H.

PY - 1974

Y1 - 1974

N2 - CATECHOL-O-METHYLTRANSFERASE (COMT) is the enzyme that catalyses the conversion of noradrenaline, adrenaline, dopamine, and other catechol compounds to their O-methylated metabolites1. COMT is widely distributed in many tissues including the red blood cell (RBC)1,2 and individual differences in the activity of this enzyme in human beings may be involved in the pathogenesis of various psychiatric and neurological diseases3,4. Inhibitors of COMT have been used experimentally in the treatment of Parkinson's disease and other neurological diseases5. COMT activity is decreased in red blood cells obtained from depressed women3 and is increased in erythrocytes obtained from children with Down's syndrome 6.

AB - CATECHOL-O-METHYLTRANSFERASE (COMT) is the enzyme that catalyses the conversion of noradrenaline, adrenaline, dopamine, and other catechol compounds to their O-methylated metabolites1. COMT is widely distributed in many tissues including the red blood cell (RBC)1,2 and individual differences in the activity of this enzyme in human beings may be involved in the pathogenesis of various psychiatric and neurological diseases3,4. Inhibitors of COMT have been used experimentally in the treatment of Parkinson's disease and other neurological diseases5. COMT activity is decreased in red blood cells obtained from depressed women3 and is increased in erythrocytes obtained from children with Down's syndrome 6.

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JF - Nature

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ER -

Correlation of erythrocyte catechol-O-methyltransferase activity between siblings

Abstract

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