Correlation of erythrocyte catechol O methyltransferase activity between siblings

Richard M Weinshilboum, F. A. Raymond, L. R. Elveback, W. H. Weidman

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A study of erythrocyte catechol O methyltransferase (COMT) activity in blood obtained from a large, unselected population of young men and women is described, the results of which demonstrate a significant correlation of COMT activity between siblings and suggest that there may be at least 2 human populations with regard to levels of activity of this catecholamine degradative enzyme activity in the erythrocytes. The data that have been presented here with regard to a sibling sibling correlation of COMT activity may represent an additional example of the importance of familial factors in the regulation of the activities of catecholamine biosynthetic and degradative enzymes in man. Although red blood cell COMT is biochemically similar to COMT in other tissues, the identity of erythrocyte COMT with COMT in other human tissues has not been established.

Original languageEnglish (US)
Pages (from-to)490-491
Number of pages2
JournalNature
Volume252
Issue number5483
StatePublished - 1974

Fingerprint

Catechol O-Methyltransferase
Siblings
Erythrocytes
Catecholamines
Enzymes
Population

ASJC Scopus subject areas

  • General

Cite this

Weinshilboum, R. M., Raymond, F. A., Elveback, L. R., & Weidman, W. H. (1974). Correlation of erythrocyte catechol O methyltransferase activity between siblings. Nature, 252(5483), 490-491.

Correlation of erythrocyte catechol O methyltransferase activity between siblings. / Weinshilboum, Richard M; Raymond, F. A.; Elveback, L. R.; Weidman, W. H.

In: Nature, Vol. 252, No. 5483, 1974, p. 490-491.

Research output: Contribution to journalArticle

Weinshilboum, RM, Raymond, FA, Elveback, LR & Weidman, WH 1974, 'Correlation of erythrocyte catechol O methyltransferase activity between siblings', Nature, vol. 252, no. 5483, pp. 490-491.
Weinshilboum, Richard M ; Raymond, F. A. ; Elveback, L. R. ; Weidman, W. H. / Correlation of erythrocyte catechol O methyltransferase activity between siblings. In: Nature. 1974 ; Vol. 252, No. 5483. pp. 490-491.
@article{4da3c59b4bf34ee787f1e46348329363,
title = "Correlation of erythrocyte catechol O methyltransferase activity between siblings",
abstract = "A study of erythrocyte catechol O methyltransferase (COMT) activity in blood obtained from a large, unselected population of young men and women is described, the results of which demonstrate a significant correlation of COMT activity between siblings and suggest that there may be at least 2 human populations with regard to levels of activity of this catecholamine degradative enzyme activity in the erythrocytes. The data that have been presented here with regard to a sibling sibling correlation of COMT activity may represent an additional example of the importance of familial factors in the regulation of the activities of catecholamine biosynthetic and degradative enzymes in man. Although red blood cell COMT is biochemically similar to COMT in other tissues, the identity of erythrocyte COMT with COMT in other human tissues has not been established.",
author = "Weinshilboum, {Richard M} and Raymond, {F. A.} and Elveback, {L. R.} and Weidman, {W. H.}",
year = "1974",
language = "English (US)",
volume = "252",
pages = "490--491",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "5483",

}

TY - JOUR

T1 - Correlation of erythrocyte catechol O methyltransferase activity between siblings

AU - Weinshilboum, Richard M

AU - Raymond, F. A.

AU - Elveback, L. R.

AU - Weidman, W. H.

PY - 1974

Y1 - 1974

N2 - A study of erythrocyte catechol O methyltransferase (COMT) activity in blood obtained from a large, unselected population of young men and women is described, the results of which demonstrate a significant correlation of COMT activity between siblings and suggest that there may be at least 2 human populations with regard to levels of activity of this catecholamine degradative enzyme activity in the erythrocytes. The data that have been presented here with regard to a sibling sibling correlation of COMT activity may represent an additional example of the importance of familial factors in the regulation of the activities of catecholamine biosynthetic and degradative enzymes in man. Although red blood cell COMT is biochemically similar to COMT in other tissues, the identity of erythrocyte COMT with COMT in other human tissues has not been established.

AB - A study of erythrocyte catechol O methyltransferase (COMT) activity in blood obtained from a large, unselected population of young men and women is described, the results of which demonstrate a significant correlation of COMT activity between siblings and suggest that there may be at least 2 human populations with regard to levels of activity of this catecholamine degradative enzyme activity in the erythrocytes. The data that have been presented here with regard to a sibling sibling correlation of COMT activity may represent an additional example of the importance of familial factors in the regulation of the activities of catecholamine biosynthetic and degradative enzymes in man. Although red blood cell COMT is biochemically similar to COMT in other tissues, the identity of erythrocyte COMT with COMT in other human tissues has not been established.

UR - http://www.scopus.com/inward/record.url?scp=0016144741&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016144741&partnerID=8YFLogxK

M3 - Article

VL - 252

SP - 490

EP - 491

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5483

ER -