Correlation of clinical outcome with the degree of surface immunoglobulin (sIg) expression in B-cell chronic lymphocytic leukemia

Ayalew Tefferi, C. Y. Li, R. L. Phyliky

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Peripheral blood from 121 consecutive patients with B-cell chronic lymphocytic leukemia (B-CLL) was immunophenotyped, and three groups with differing surface immunoglobulin (sIg) expression patterns were identified: Group A, 82 patients (68%) with weak sIg expression in greater than 20% of the circulating lymphocytes; Group B, 16 patients (13%) with either undetectable sIg or weak sIg expression limited to less than 20% of the lymphocytes; and Group C, 23 patients (19%) with strong sIg expression in greater than 20% of the lymphocytes. The histories of these patients were reviewed retrospectively, and the median follow-up in Groups A, B, and C was nine, ten, and nine years, respectively. Disease progression, defined as the development of cytopenia(s) (hemoglobin ≤100 g/L [≤10 g/dL] or platelet count <100 x 109/L [<100 x 103 μL]) and/or the development of newly palpable splenomegaly or lymphadenopathy, was least in Group B (6%) versus Group A (34%) versus Group C (30%) (P = 0.08). The incidence of hypogammaglobulinemia among patients who had protein electrophoresis performed was 7% in Group B versus 46% in Group A versus 45% in Group C (P = 0.036). The authors conclude that adult patients with B-CLL in whom sIg is undetectable or weakly expressed in less than 20% of the circulating lymphocytes may have an even more indolent clinical course than those with more widespread sIg expression.

Original languageEnglish (US)
Pages (from-to)82-85
Number of pages4
JournalAmerican Journal of Clinical Pathology
Volume92
Issue number1
StatePublished - 1989

Fingerprint

B-Cell Antigen Receptors
B-Cell Chronic Lymphocytic Leukemia
Lymphocytes
Agammaglobulinemia
Splenomegaly
Platelet Count
Disease Progression
Electrophoresis
Hemoglobins
Incidence

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

@article{0855dbde729d483599070c164e00a129,
title = "Correlation of clinical outcome with the degree of surface immunoglobulin (sIg) expression in B-cell chronic lymphocytic leukemia",
abstract = "Peripheral blood from 121 consecutive patients with B-cell chronic lymphocytic leukemia (B-CLL) was immunophenotyped, and three groups with differing surface immunoglobulin (sIg) expression patterns were identified: Group A, 82 patients (68{\%}) with weak sIg expression in greater than 20{\%} of the circulating lymphocytes; Group B, 16 patients (13{\%}) with either undetectable sIg or weak sIg expression limited to less than 20{\%} of the lymphocytes; and Group C, 23 patients (19{\%}) with strong sIg expression in greater than 20{\%} of the lymphocytes. The histories of these patients were reviewed retrospectively, and the median follow-up in Groups A, B, and C was nine, ten, and nine years, respectively. Disease progression, defined as the development of cytopenia(s) (hemoglobin ≤100 g/L [≤10 g/dL] or platelet count <100 x 109/L [<100 x 103 μL]) and/or the development of newly palpable splenomegaly or lymphadenopathy, was least in Group B (6{\%}) versus Group A (34{\%}) versus Group C (30{\%}) (P = 0.08). The incidence of hypogammaglobulinemia among patients who had protein electrophoresis performed was 7{\%} in Group B versus 46{\%} in Group A versus 45{\%} in Group C (P = 0.036). The authors conclude that adult patients with B-CLL in whom sIg is undetectable or weakly expressed in less than 20{\%} of the circulating lymphocytes may have an even more indolent clinical course than those with more widespread sIg expression.",
author = "Ayalew Tefferi and Li, {C. Y.} and Phyliky, {R. L.}",
year = "1989",
language = "English (US)",
volume = "92",
pages = "82--85",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "1",

}

TY - JOUR

T1 - Correlation of clinical outcome with the degree of surface immunoglobulin (sIg) expression in B-cell chronic lymphocytic leukemia

AU - Tefferi, Ayalew

AU - Li, C. Y.

AU - Phyliky, R. L.

PY - 1989

Y1 - 1989

N2 - Peripheral blood from 121 consecutive patients with B-cell chronic lymphocytic leukemia (B-CLL) was immunophenotyped, and three groups with differing surface immunoglobulin (sIg) expression patterns were identified: Group A, 82 patients (68%) with weak sIg expression in greater than 20% of the circulating lymphocytes; Group B, 16 patients (13%) with either undetectable sIg or weak sIg expression limited to less than 20% of the lymphocytes; and Group C, 23 patients (19%) with strong sIg expression in greater than 20% of the lymphocytes. The histories of these patients were reviewed retrospectively, and the median follow-up in Groups A, B, and C was nine, ten, and nine years, respectively. Disease progression, defined as the development of cytopenia(s) (hemoglobin ≤100 g/L [≤10 g/dL] or platelet count <100 x 109/L [<100 x 103 μL]) and/or the development of newly palpable splenomegaly or lymphadenopathy, was least in Group B (6%) versus Group A (34%) versus Group C (30%) (P = 0.08). The incidence of hypogammaglobulinemia among patients who had protein electrophoresis performed was 7% in Group B versus 46% in Group A versus 45% in Group C (P = 0.036). The authors conclude that adult patients with B-CLL in whom sIg is undetectable or weakly expressed in less than 20% of the circulating lymphocytes may have an even more indolent clinical course than those with more widespread sIg expression.

AB - Peripheral blood from 121 consecutive patients with B-cell chronic lymphocytic leukemia (B-CLL) was immunophenotyped, and three groups with differing surface immunoglobulin (sIg) expression patterns were identified: Group A, 82 patients (68%) with weak sIg expression in greater than 20% of the circulating lymphocytes; Group B, 16 patients (13%) with either undetectable sIg or weak sIg expression limited to less than 20% of the lymphocytes; and Group C, 23 patients (19%) with strong sIg expression in greater than 20% of the lymphocytes. The histories of these patients were reviewed retrospectively, and the median follow-up in Groups A, B, and C was nine, ten, and nine years, respectively. Disease progression, defined as the development of cytopenia(s) (hemoglobin ≤100 g/L [≤10 g/dL] or platelet count <100 x 109/L [<100 x 103 μL]) and/or the development of newly palpable splenomegaly or lymphadenopathy, was least in Group B (6%) versus Group A (34%) versus Group C (30%) (P = 0.08). The incidence of hypogammaglobulinemia among patients who had protein electrophoresis performed was 7% in Group B versus 46% in Group A versus 45% in Group C (P = 0.036). The authors conclude that adult patients with B-CLL in whom sIg is undetectable or weakly expressed in less than 20% of the circulating lymphocytes may have an even more indolent clinical course than those with more widespread sIg expression.

UR - http://www.scopus.com/inward/record.url?scp=0024346535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024346535&partnerID=8YFLogxK

M3 - Article

VL - 92

SP - 82

EP - 85

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 1

ER -