TY - JOUR
T1 - Correlation of bone mineral density scores and proton pump inhibitors use in the elderly
AU - Amoako, Adae O.
AU - Jafilan, Lena
AU - Nasiri, Papia
AU - Pujalte, George G.A.
N1 - Publisher Copyright:
© 2016 Bentham Science Publishers.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Objective: We aimed to identify any correlation between long-term proton pump inhibitor use and low bone mineral density in the elderly. Materials and Methods: This is a retrospective cohort study looking at PPI usage and bone mineral density scores of patients age 65 and above within a period of two years. Lumbar spine, right hip, and left hip bone mineral density t-scores were reviewed in PPI users and non-users. Results: A total of 1,016 patients who had bone mineral density scans within that period were identified. Non-adjusted data showed no statistically significant association between PPI users and non-users in lumbar spine (p = 0.903), right hip (p = 0.775) and left hip (p = 0.407) bone mineral density scores. After adjusting for age and gender, PPI use was still not associated with low bone mineral density at the lumbar spine (p = 0.957), right hip (p = 0.440), or left hip (p = 0.691). The logistic regression did not show a statistically significant difference in low bone mineral density scores in lumbar spine (p = 0.162), right hip (p = 0.796), and left hip (p = 0.196) when length of use was considered. Conclusion: Among adults 65 years and older proton pump inhibitors users; there appears to be no correlation between PPI use and low bone mineral density and/or the length of PPI use.
AB - Objective: We aimed to identify any correlation between long-term proton pump inhibitor use and low bone mineral density in the elderly. Materials and Methods: This is a retrospective cohort study looking at PPI usage and bone mineral density scores of patients age 65 and above within a period of two years. Lumbar spine, right hip, and left hip bone mineral density t-scores were reviewed in PPI users and non-users. Results: A total of 1,016 patients who had bone mineral density scans within that period were identified. Non-adjusted data showed no statistically significant association between PPI users and non-users in lumbar spine (p = 0.903), right hip (p = 0.775) and left hip (p = 0.407) bone mineral density scores. After adjusting for age and gender, PPI use was still not associated with low bone mineral density at the lumbar spine (p = 0.957), right hip (p = 0.440), or left hip (p = 0.691). The logistic regression did not show a statistically significant difference in low bone mineral density scores in lumbar spine (p = 0.162), right hip (p = 0.796), and left hip (p = 0.196) when length of use was considered. Conclusion: Among adults 65 years and older proton pump inhibitors users; there appears to be no correlation between PPI use and low bone mineral density and/or the length of PPI use.
KW - Bone density
KW - Fracture
KW - Osteoporosis
KW - Proton-pump inhibitor
UR - http://www.scopus.com/inward/record.url?scp=84975815196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975815196&partnerID=8YFLogxK
U2 - 10.2174/1573397111666151026222921
DO - 10.2174/1573397111666151026222921
M3 - Article
C2 - 26496778
AN - SCOPUS:84975815196
SN - 1573-3971
VL - 12
SP - 162
EP - 166
JO - Current Rheumatology Reviews
JF - Current Rheumatology Reviews
IS - 2
ER -