Correlation of blood pressure in normotensive and hypertensive individuals with platelet but not lymphocyte intracellular free calcium concentrations

K. Pritchard, A. E G Raine, C. C. Ashley, L. M. Castell, Virend Somers, C. Osborn, J. G G Ledingham, J. Conway

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

1. Fifty-two normotensive and essential hypertensive subjects were studied. Intracellular free calcium concentration ([Ca2+](i)) was measured in lymphocytes (37 subjects) and platelets (18 subjects) by means of the fluorescent indicators, quin 2 and fura-2. In 31 subjects, plasma ionized calcium concentration was also measured. 2. There was a positive correlation between platelet [Ca2+](i) and sytolic blood pressure (r = 0.485, P < 0.05), diastolic blood pressure (r = 0.542, P < 0.02) and mean blood pressure (r = 0.534, P < 0.02). 3. No statistically significant relationship was observed between plasma ionized calcium and blood pressure. 4. No relationship was found between lymphocyte [Ca2+](i) and blood pressure, or between lymphocyte [Ca2+](i) and plasma ionized calcium. 5. There was no relationship between [Ca2+](i) of lymphocytes and platelets measured simultaneously from the same subject. 6. These findings reconcile previous conflicting reports and show a relationship between platelet but not lymphocyte [Ca2+](i) and blood pressure in man.

Original languageEnglish (US)
Pages (from-to)631-635
Number of pages5
JournalClinical Science
Volume76
Issue number6
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Pritchard, K., Raine, A. E. G., Ashley, C. C., Castell, L. M., Somers, V., Osborn, C., Ledingham, J. G. G., & Conway, J. (1989). Correlation of blood pressure in normotensive and hypertensive individuals with platelet but not lymphocyte intracellular free calcium concentrations. Clinical Science, 76(6), 631-635.