Correlation of blood pressure in normotensive and hypertensive individuals with platelet but not lymphocyte intracellular free calcium concentrations

K. Pritchard, A. E.G. Raine, C. C. Ashley, L. M. Castell, V. Somers, C. Osborn, J. G.G. Ledingham, J. Conway

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

1. Fifty-two normotensive and essential hypertensive subjects were studied. Intracellular free calcium concentration ([Ca2+](i)) was measured in lymphocytes (37 subjects) and platelets (18 subjects) by means of the fluorescent indicators, quin 2 and fura-2. In 31 subjects, plasma ionized calcium concentration was also measured. 2. There was a positive correlation between platelet [Ca2+](i) and sytolic blood pressure (r = 0.485, P < 0.05), diastolic blood pressure (r = 0.542, P < 0.02) and mean blood pressure (r = 0.534, P < 0.02). 3. No statistically significant relationship was observed between plasma ionized calcium and blood pressure. 4. No relationship was found between lymphocyte [Ca2+](i) and blood pressure, or between lymphocyte [Ca2+](i) and plasma ionized calcium. 5. There was no relationship between [Ca2+](i) of lymphocytes and platelets measured simultaneously from the same subject. 6. These findings reconcile previous conflicting reports and show a relationship between platelet but not lymphocyte [Ca2+](i) and blood pressure in man.

Original languageEnglish (US)
Pages (from-to)631-635
Number of pages5
JournalClinical Science
Volume76
Issue number6
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Medicine(all)

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