Correlation of [18F]-2-fluoro-deoxy-D-glucose positron emission tomography standard uptake values with the cellular composition of stage I nonsmall cell lung cancer

Jared D. Christensen, Tom V. Colby, Edward F. Patz

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

BACKGROUND: The aim of the current study was to determine whether the [18F]-2-fluoro-deoxy-D-glucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) in patients with a new diagnosis of stage I lung cancer correlates with a specific cellular component in the primary tumor. METHODS: This study was Health Insurance Portability and Accountability Act compliant and approved by our Institutional Review Board with a waiver of informed consent. Forty patients with stage I nonsmall cell lung cancer (NSCLC) who underwent FDG-PET imaging at the time of diagnosis followed by surgical resection were retrospectively identified. Histologic sections of the primary tumor were reviewed by a pathologist without any clinical data and scored according to the percentage of each cellular component (tumor cells, normal stroma, inflammatory cells, necrosis, fibrosis, and other). Each component was compared with maximal (SUVmax) and mean (SUVmean) SUVs using Pearson correlation coefficient analysis. RESULTS: The mean SUV max and SUVmean values for 40 stage I NSCLC tumors were 8.8 and 5.4, respectively. The mean histologic composition of tumor specimens in order of frequency was as follows: tumor cells (38.9%), fibrosis (30.8%), inflammatory cells (14.8%), normal stroma (5.2%), necrosis (5.8%), and other components (4.5%); however, there was considerable variation noted among individual tumors. There was no statistically significant correlation between SUVmax (r=.19; P=.24) or SUVmean (r=.017; P=.29) and the proportion of tumor cells in the tumor mass or any other cellular components. CONCLUSIONS: The cellular composition of stage I NSCLC appears to be highly variable, with no correlation noted between a specific tumor cellular component and FDG activity.

Original languageEnglish (US)
Pages (from-to)4095-4102
Number of pages8
JournalCancer
Volume116
Issue number17
DOIs
StatePublished - Sep 1 2010

Fingerprint

Deoxyglucose
Non-Small Cell Lung Carcinoma
Positron-Emission Tomography
Neoplasms
Fibrosis
Necrosis
Health Insurance Portability and Accountability Act
Glucose
Research Ethics Committees
Cellular Structures
Informed Consent
Lung Neoplasms

Keywords

  • Diagnostic imaging
  • Neoplasm staging
  • Nonsmall cell lung carcinoma
  • Pathology
  • Positron emission tomography

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Correlation of [18F]-2-fluoro-deoxy-D-glucose positron emission tomography standard uptake values with the cellular composition of stage I nonsmall cell lung cancer. / Christensen, Jared D.; Colby, Tom V.; Patz, Edward F.

In: Cancer, Vol. 116, No. 17, 01.09.2010, p. 4095-4102.

Research output: Contribution to journalArticle

@article{bef6a2353059414fa4cfb89ffa43fad2,
title = "Correlation of [18F]-2-fluoro-deoxy-D-glucose positron emission tomography standard uptake values with the cellular composition of stage I nonsmall cell lung cancer",
abstract = "BACKGROUND: The aim of the current study was to determine whether the [18F]-2-fluoro-deoxy-D-glucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) in patients with a new diagnosis of stage I lung cancer correlates with a specific cellular component in the primary tumor. METHODS: This study was Health Insurance Portability and Accountability Act compliant and approved by our Institutional Review Board with a waiver of informed consent. Forty patients with stage I nonsmall cell lung cancer (NSCLC) who underwent FDG-PET imaging at the time of diagnosis followed by surgical resection were retrospectively identified. Histologic sections of the primary tumor were reviewed by a pathologist without any clinical data and scored according to the percentage of each cellular component (tumor cells, normal stroma, inflammatory cells, necrosis, fibrosis, and other). Each component was compared with maximal (SUVmax) and mean (SUVmean) SUVs using Pearson correlation coefficient analysis. RESULTS: The mean SUV max and SUVmean values for 40 stage I NSCLC tumors were 8.8 and 5.4, respectively. The mean histologic composition of tumor specimens in order of frequency was as follows: tumor cells (38.9{\%}), fibrosis (30.8{\%}), inflammatory cells (14.8{\%}), normal stroma (5.2{\%}), necrosis (5.8{\%}), and other components (4.5{\%}); however, there was considerable variation noted among individual tumors. There was no statistically significant correlation between SUVmax (r=.19; P=.24) or SUVmean (r=.017; P=.29) and the proportion of tumor cells in the tumor mass or any other cellular components. CONCLUSIONS: The cellular composition of stage I NSCLC appears to be highly variable, with no correlation noted between a specific tumor cellular component and FDG activity.",
keywords = "Diagnostic imaging, Neoplasm staging, Nonsmall cell lung carcinoma, Pathology, Positron emission tomography",
author = "Christensen, {Jared D.} and Colby, {Tom V.} and Patz, {Edward F.}",
year = "2010",
month = "9",
day = "1",
doi = "10.1002/cncr.25302",
language = "English (US)",
volume = "116",
pages = "4095--4102",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "17",

}

TY - JOUR

T1 - Correlation of [18F]-2-fluoro-deoxy-D-glucose positron emission tomography standard uptake values with the cellular composition of stage I nonsmall cell lung cancer

AU - Christensen, Jared D.

AU - Colby, Tom V.

AU - Patz, Edward F.

PY - 2010/9/1

Y1 - 2010/9/1

N2 - BACKGROUND: The aim of the current study was to determine whether the [18F]-2-fluoro-deoxy-D-glucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) in patients with a new diagnosis of stage I lung cancer correlates with a specific cellular component in the primary tumor. METHODS: This study was Health Insurance Portability and Accountability Act compliant and approved by our Institutional Review Board with a waiver of informed consent. Forty patients with stage I nonsmall cell lung cancer (NSCLC) who underwent FDG-PET imaging at the time of diagnosis followed by surgical resection were retrospectively identified. Histologic sections of the primary tumor were reviewed by a pathologist without any clinical data and scored according to the percentage of each cellular component (tumor cells, normal stroma, inflammatory cells, necrosis, fibrosis, and other). Each component was compared with maximal (SUVmax) and mean (SUVmean) SUVs using Pearson correlation coefficient analysis. RESULTS: The mean SUV max and SUVmean values for 40 stage I NSCLC tumors were 8.8 and 5.4, respectively. The mean histologic composition of tumor specimens in order of frequency was as follows: tumor cells (38.9%), fibrosis (30.8%), inflammatory cells (14.8%), normal stroma (5.2%), necrosis (5.8%), and other components (4.5%); however, there was considerable variation noted among individual tumors. There was no statistically significant correlation between SUVmax (r=.19; P=.24) or SUVmean (r=.017; P=.29) and the proportion of tumor cells in the tumor mass or any other cellular components. CONCLUSIONS: The cellular composition of stage I NSCLC appears to be highly variable, with no correlation noted between a specific tumor cellular component and FDG activity.

AB - BACKGROUND: The aim of the current study was to determine whether the [18F]-2-fluoro-deoxy-D-glucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) in patients with a new diagnosis of stage I lung cancer correlates with a specific cellular component in the primary tumor. METHODS: This study was Health Insurance Portability and Accountability Act compliant and approved by our Institutional Review Board with a waiver of informed consent. Forty patients with stage I nonsmall cell lung cancer (NSCLC) who underwent FDG-PET imaging at the time of diagnosis followed by surgical resection were retrospectively identified. Histologic sections of the primary tumor were reviewed by a pathologist without any clinical data and scored according to the percentage of each cellular component (tumor cells, normal stroma, inflammatory cells, necrosis, fibrosis, and other). Each component was compared with maximal (SUVmax) and mean (SUVmean) SUVs using Pearson correlation coefficient analysis. RESULTS: The mean SUV max and SUVmean values for 40 stage I NSCLC tumors were 8.8 and 5.4, respectively. The mean histologic composition of tumor specimens in order of frequency was as follows: tumor cells (38.9%), fibrosis (30.8%), inflammatory cells (14.8%), normal stroma (5.2%), necrosis (5.8%), and other components (4.5%); however, there was considerable variation noted among individual tumors. There was no statistically significant correlation between SUVmax (r=.19; P=.24) or SUVmean (r=.017; P=.29) and the proportion of tumor cells in the tumor mass or any other cellular components. CONCLUSIONS: The cellular composition of stage I NSCLC appears to be highly variable, with no correlation noted between a specific tumor cellular component and FDG activity.

KW - Diagnostic imaging

KW - Neoplasm staging

KW - Nonsmall cell lung carcinoma

KW - Pathology

KW - Positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=77956807447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956807447&partnerID=8YFLogxK

U2 - 10.1002/cncr.25302

DO - 10.1002/cncr.25302

M3 - Article

C2 - 20533438

AN - SCOPUS:77956807447

VL - 116

SP - 4095

EP - 4102

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 17

ER -