Correlation between the movement disorder society’s unified parkinson’s disease rating scale and nonmotor scales in patients with parkinson’s disease

Erika M Driver-Dunckley, N. A.N. Zhang, Holly A. Shill, Shyamal H. Mehta, Christine M. Belden, Edward Y. Zamrini, Kathryn Davis, Thomas G. Beach, Charles H. Adler

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: The Movement Disorder Society’s Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), Scales for Outcomes in Parkinson’s Disease–Autonomic (SCOPA-AUT), Mayo Sleep Questionnaire, Epworth Sleepiness Scale, and Neuropsychiatric Inventory Questionnaire (NPI-Q) are validated instruments for assessing signs and symptoms of Parkinson’s disease (PD). Objective: We sought to determine whether responses on the MDS-UPDRS correlate with responses to other scales used in patients with PD. Design: Study subjects were enrolled in the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND). Participants were selected if they had completed all scales within a one-month window. Spearman’s rank correlation coefficients were calculated. Results: A total of 96 eligible subjects were identified. High correlation (r-values) was found between the SCOPA-AUT and MDS-UPDRS excessive saliva (0.73; p<0.001), constipation (0.62; p<0.001), and swallowing (0.59; p<0.001) questions. The r-values for the NPI-Q and MDS-UPDRS depression and anxiety questions were 0.53 (p<0.001), and 0.67 (p<0.001). Conclusion: MDS-UPDRS correlates well with some but not all questions from the SCOPA-AUT and NPI-Q. This work emphasizes the importance of employing multiple methods for assessing nonmotor symptoms in patients with PD.

Original languageEnglish (US)
Pages (from-to)27-29
Number of pages3
JournalInnovations in Clinical Neuroscience
Volume16
Issue number9-10
StatePublished - Sep 1 2019

Keywords

  • ESS
  • MDS-UPDRS
  • MSQ
  • NPI-Q
  • Parkinson’s disease
  • SCOPA-AUT

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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