Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity

Pritish K. Tosh, Richard B Kennedy, Robert A. Vierkant, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Despite a safe and effective vaccine, endemic rubella remains a problem in developing countries. Isolated cases and outbreaks can occur in areas with high vaccine coverage. Individuals, especially pregnant women who remain unimmunized or do not seroconvert, are susceptible to infection and their infants are at risk for congenital rubella syndrome (CRS). Both humoral and cellular immune responses contribute to immune protection. Classically, immunity to rubella has been assessed through the detection of rubella-specific antibody titers. In this study we examined correlates of both humoral and cellular immunity in a large population of immunized young adults in Olmsted County, MN. We were unable to find any significant correlation between cytokine production after in-vitro rubella stimulation and serum antibody titers.

Original languageEnglish (US)
Pages (from-to)451-456
Number of pages6
JournalViral Immunology
Volume22
Issue number6
DOIs
StatePublished - Dec 1 2009

Fingerprint

Rubella
Humoral Immunity
Cellular Immunity
Congenital Rubella Syndrome
Rubella Vaccine
Cytokines
Developing Countries
Disease Outbreaks
Pregnant Women
Young Adult
Immunity
Vaccines
Antibodies
Infection
Serum
Population
rubella antibodies
In Vitro Techniques

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology
  • Virology

Cite this

Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity. / Tosh, Pritish K.; Kennedy, Richard B; Vierkant, Robert A.; Jacobson, Robert M.; Poland, Gregory A.

In: Viral Immunology, Vol. 22, No. 6, 01.12.2009, p. 451-456.

Research output: Contribution to journalArticle

Tosh, Pritish K. ; Kennedy, Richard B ; Vierkant, Robert A. ; Jacobson, Robert M. ; Poland, Gregory A. / Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity. In: Viral Immunology. 2009 ; Vol. 22, No. 6. pp. 451-456.
@article{76bf82446e294a38ad35b9ff044335ee,
title = "Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity",
abstract = "Despite a safe and effective vaccine, endemic rubella remains a problem in developing countries. Isolated cases and outbreaks can occur in areas with high vaccine coverage. Individuals, especially pregnant women who remain unimmunized or do not seroconvert, are susceptible to infection and their infants are at risk for congenital rubella syndrome (CRS). Both humoral and cellular immune responses contribute to immune protection. Classically, immunity to rubella has been assessed through the detection of rubella-specific antibody titers. In this study we examined correlates of both humoral and cellular immunity in a large population of immunized young adults in Olmsted County, MN. We were unable to find any significant correlation between cytokine production after in-vitro rubella stimulation and serum antibody titers.",
author = "Tosh, {Pritish K.} and Kennedy, {Richard B} and Vierkant, {Robert A.} and Jacobson, {Robert M.} and Poland, {Gregory A.}",
year = "2009",
month = "12",
day = "1",
doi = "10.1089/vim.2009.0068",
language = "English (US)",
volume = "22",
pages = "451--456",
journal = "Viral Immunology",
issn = "0882-8245",
publisher = "Mary Ann Liebert Inc.",
number = "6",

}

TY - JOUR

T1 - Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity

AU - Tosh, Pritish K.

AU - Kennedy, Richard B

AU - Vierkant, Robert A.

AU - Jacobson, Robert M.

AU - Poland, Gregory A.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Despite a safe and effective vaccine, endemic rubella remains a problem in developing countries. Isolated cases and outbreaks can occur in areas with high vaccine coverage. Individuals, especially pregnant women who remain unimmunized or do not seroconvert, are susceptible to infection and their infants are at risk for congenital rubella syndrome (CRS). Both humoral and cellular immune responses contribute to immune protection. Classically, immunity to rubella has been assessed through the detection of rubella-specific antibody titers. In this study we examined correlates of both humoral and cellular immunity in a large population of immunized young adults in Olmsted County, MN. We were unable to find any significant correlation between cytokine production after in-vitro rubella stimulation and serum antibody titers.

AB - Despite a safe and effective vaccine, endemic rubella remains a problem in developing countries. Isolated cases and outbreaks can occur in areas with high vaccine coverage. Individuals, especially pregnant women who remain unimmunized or do not seroconvert, are susceptible to infection and their infants are at risk for congenital rubella syndrome (CRS). Both humoral and cellular immune responses contribute to immune protection. Classically, immunity to rubella has been assessed through the detection of rubella-specific antibody titers. In this study we examined correlates of both humoral and cellular immunity in a large population of immunized young adults in Olmsted County, MN. We were unable to find any significant correlation between cytokine production after in-vitro rubella stimulation and serum antibody titers.

UR - http://www.scopus.com/inward/record.url?scp=71449085221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71449085221&partnerID=8YFLogxK

U2 - 10.1089/vim.2009.0068

DO - 10.1089/vim.2009.0068

M3 - Article

C2 - 19951182

AN - SCOPUS:71449085221

VL - 22

SP - 451

EP - 456

JO - Viral Immunology

JF - Viral Immunology

SN - 0882-8245

IS - 6

ER -