Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity

Pritish K. Tosh; Richard B. Kennedy; Robert A. Vierkant; Robert M. Jacobson; Gregory A. Poland

doi:10.1089/vim.2009.0068

Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity

Pritish K. Tosh, Richard B. Kennedy, Robert A. Vierkant, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Despite a safe and effective vaccine, endemic rubella remains a problem in developing countries. Isolated cases and outbreaks can occur in areas with high vaccine coverage. Individuals, especially pregnant women who remain unimmunized or do not seroconvert, are susceptible to infection and their infants are at risk for congenital rubella syndrome (CRS). Both humoral and cellular immune responses contribute to immune protection. Classically, immunity to rubella has been assessed through the detection of rubella-specific antibody titers. In this study we examined correlates of both humoral and cellular immunity in a large population of immunized young adults in Olmsted County, MN. We were unable to find any significant correlation between cytokine production after in-vitro rubella stimulation and serum antibody titers.

Original language	English (US)
Pages (from-to)	451-456
Number of pages	6
Journal	Viral Immunology
Volume	22
Issue number	6
DOIs	https://doi.org/10.1089/vim.2009.0068
State	Published - Dec 1 2009

ASJC Scopus subject areas

Immunology
Molecular Medicine
Virology

Access to Document

10.1089/vim.2009.0068

Cite this

@article{76bf82446e294a38ad35b9ff044335ee,

title = "Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity",

abstract = "Despite a safe and effective vaccine, endemic rubella remains a problem in developing countries. Isolated cases and outbreaks can occur in areas with high vaccine coverage. Individuals, especially pregnant women who remain unimmunized or do not seroconvert, are susceptible to infection and their infants are at risk for congenital rubella syndrome (CRS). Both humoral and cellular immune responses contribute to immune protection. Classically, immunity to rubella has been assessed through the detection of rubella-specific antibody titers. In this study we examined correlates of both humoral and cellular immunity in a large population of immunized young adults in Olmsted County, MN. We were unable to find any significant correlation between cytokine production after in-vitro rubella stimulation and serum antibody titers.",

author = "Tosh, {Pritish K.} and Kennedy, {Richard B.} and Vierkant, {Robert A.} and Jacobson, {Robert M.} and Poland, {Gregory A.}",

year = "2009",

month = dec,

day = "1",

doi = "10.1089/vim.2009.0068",

language = "English (US)",

volume = "22",

pages = "451--456",

journal = "Viral Immunology",

issn = "0882-8245",

publisher = "Mary Ann Liebert Inc.",

number = "6",

}

TY - JOUR

T1 - Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity

AU - Tosh, Pritish K.

AU - Kennedy, Richard B.

AU - Vierkant, Robert A.

AU - Jacobson, Robert M.

AU - Poland, Gregory A.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Despite a safe and effective vaccine, endemic rubella remains a problem in developing countries. Isolated cases and outbreaks can occur in areas with high vaccine coverage. Individuals, especially pregnant women who remain unimmunized or do not seroconvert, are susceptible to infection and their infants are at risk for congenital rubella syndrome (CRS). Both humoral and cellular immune responses contribute to immune protection. Classically, immunity to rubella has been assessed through the detection of rubella-specific antibody titers. In this study we examined correlates of both humoral and cellular immunity in a large population of immunized young adults in Olmsted County, MN. We were unable to find any significant correlation between cytokine production after in-vitro rubella stimulation and serum antibody titers.

AB - Despite a safe and effective vaccine, endemic rubella remains a problem in developing countries. Isolated cases and outbreaks can occur in areas with high vaccine coverage. Individuals, especially pregnant women who remain unimmunized or do not seroconvert, are susceptible to infection and their infants are at risk for congenital rubella syndrome (CRS). Both humoral and cellular immune responses contribute to immune protection. Classically, immunity to rubella has been assessed through the detection of rubella-specific antibody titers. In this study we examined correlates of both humoral and cellular immunity in a large population of immunized young adults in Olmsted County, MN. We were unable to find any significant correlation between cytokine production after in-vitro rubella stimulation and serum antibody titers.

UR - http://www.scopus.com/inward/record.url?scp=71449085221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71449085221&partnerID=8YFLogxK

U2 - 10.1089/vim.2009.0068

DO - 10.1089/vim.2009.0068

M3 - Article

C2 - 19951182

AN - SCOPUS:71449085221

SN - 0882-8245

VL - 22

SP - 451

EP - 456

JO - Viral Immunology

JF - Viral Immunology

IS - 6

ER -

Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this