Correlating tumor stiffness with immunohistochemical subtypes of breast cancers: Prognostic value of comb-push ultrasound shear elastography for differentiating luminal subtypes

Max Denis, Adriana Gregory, Mahdi Bayat, Robert T. Fazzio, Dana H. Whaley, Karthik Ghosh, Sejal Shah, Mostafa Fatemi, Azra Alizad

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Purpose: The purpose of our study is to correlate quantitatively measured tumor stiffness with immunohistochemical (IHC) subtypes of breast cancer. Additionally, the influence of prognostic histologic features (cancer grade, size, lymph node status, and histological type and grade) to the tumor elasticity and IHC profile relationship will be investigated. Methods: Under an institutional review board (IRB) approved protocol, B-mode ultrasound (US) and comb-push ultrasound shear elastography (CUSE) were performed on 157 female patients with suspicious breast lesions. Out of 157 patients 83 breast cancer patients confirmed by pathology were included in this study. The association between CUSE mean stiffness values and the aforementioned prognostic features of the breast cancer tumors were investigated. Results: Our results demonstrate that the most statistically significant difference (p = 0.0074) with mean elasticity is tumor size. When considering large tumors (size ≥ 8mm), thus minimizing the statistical significance of tumor size, a significant difference (p< 0.05) with mean elasticity is obtained between luminal A of histological grade I and luminal B (Ki-67 > 20%) subtypes.

Original languageEnglish (US)
Article numbere0165003
JournalPloS one
Volume11
Issue number10
DOIs
StatePublished - Oct 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint Dive into the research topics of 'Correlating tumor stiffness with immunohistochemical subtypes of breast cancers: Prognostic value of comb-push ultrasound shear elastography for differentiating luminal subtypes'. Together they form a unique fingerprint.

Cite this